Accès ouvert déclaré
2016
review
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Gregory T. Jones, Gerard Tromp, Helena Kuivaniemi, Sólveig Grétarsdóttir, Annette F. Baas, Betti Giusti, Ewa Strauss, Femke N. G. van't Hof, Tom R. Webb, Robert Erdman, Marylyn D. Ritchie, James R. Elmore, Anurag Verma, Sarah A. Pendergrass, Iftikhar J. Kullo, Zi Ye, Peggy Peissig, Omri Gottesman, Shefali S. Verma, Jennifer Malinowski, Laura J. Rasmussen‐Torvik, Kenneth M. Borthwick, Diane T. Smelser, David R. Crosslin, Mariza de Andrade, Evan J. Ryer, Catherine A. McCarty, Erwin P. Böttinger, Jennifer A. Pacheco, Dana C. Crawford, David Carrell, Glenn S. Gerhard, David P. Franklin, David J. Carey, Victoria Phillips, Michael Williams, Wenhua Wei, Ross D. Blair, Andrew A. Hill, Thodor M. Vasudevan, David R. Lewis, Ian Thomson, Jo Krysa, Geraldine B. Hill, Justin Roake, Tony R. Merriman, Grzegorz Oszkinis, Silvia Galora, Claudia Saracini, Rosanna Abbate, Raffaele Pulli, Carlo Pratesi, Athanasios Saratzis, Ana Raquel Verissimo, Suzannah Bumpstead, Stephen A. Badger, Rachel E. Clough, Gillian Cockerill, Hany Hafez, D. Scott, T. Simon Futers, Simon P.R. Romaine, Katherine Bridge, Kathryn J Griffin, Marc A. Bailey, Alberto Smith, Matthew M. Thompson, Frank M. van Bockxmeer, Stefán E. Matthíasson, Guðmar Þorleifsson, Unnur Thorsteinsdottir, Jan D. Blankensteijn, Joep A.W. Teijink, Cisca Wijmenga, Jacqueline de Graaf, Lambertus A. Kiemeney, Jes S. Lindholt, Anne E. Hughes, Declan Bradley, Kathleen Stirrups, Jonathan Golledge, Paul Norman, Janet T. Powell, Steve E. Humphries, Stephen E. Hamby, Alison H. Goodall, Christopher P. Nelson, Natzi Sakalihasan, Audrey Courtois, Robert E. Ferrell, Per Eriksson, Lasse Folkersen, Anders Franco‐Cereceda, John D. Eicher, Andrew D. Johnson, Christer Betsholtz, Arno Ruusalepp, Oscar Franzén, Eric E. Schadt, Johan Björkegren, Leonard Lipovich, Anne M. Drolet, Eric L.G. Verhoeven, Clark J. Zeebregts, Robert H. Geelkerken, M.R. van Sambeek, S.M. van Sterkenburg, Jean-Paul de Vries, Kāri Stefánsson, John R. Thompson, Paul I. W. de Bakker, Panos Deloukas, Seamus C. Harrison, André M. van Rij, Nilesh J. Samani, Matthew J. Bown
232Citations signalées, ce qui n’est pas une note de qualité
45Institutions déclarées
21Pays d’affiliation déclarés
Rattachement africain : us, es, il, Afrique du Sud, th, rs, gb, Nigéria, in, ru, pt, fr, cn, kr, ky, jp, se, bg, nl, nz, ph.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
RATIONALE: Abdominal aortic aneurysm (AAA) is a complex disease with both genetic and environmental risk factors. Together, 6 previously identified risk loci only explain a small proportion of the heritability of AAA. OBJECTIVE: To identify additional AAA risk loci using data from all available genome-wide association studies. METHODS AND RESULTS: Through a meta-analysis of 6 genome-wide association study data sets and a validation study totaling 10 204 cases and 107 766 controls, we identified 4 new AAA risk loci: 1q32.3 (SMYD2), 13q12.11 (LINC00540), 20q13.12 (near PCIF1/MMP9/ZNF335), and 21q22.2 (ERG). In various database searches, we observed no new associations between the lead AAA single nucleotide polymorphisms and coronary artery disease, blood pressure, lipids, or diabetes mellitus. Network analyses identified ERG, IL6R, and LDLR as modifiers of MMP9, with a direct interaction between ERG and MMP9. CONCLUSIONS: The 4 new risk loci for AAA seem to be specific for AAA compared with other cardiovascular diseases and related traits suggesting that traditional cardiovascular risk factor management may only have limited value in preventing the progression of aneurysmal disease.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
- Date Crossref
- 20/01/2017
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Aortic aneurysm repair treatmentsGenetic Associations and EpidemiologyConnective tissue disorders research