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Accès ouvert déclaré 2016 article

Safety of Nonsteroidal Anti‐inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study

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Résumé fourni par la source

BACKGROUND: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery. METHODS: Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien-Dindo classification (Clavien-Dindo III-V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals. RESULTS: From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60-1.34, p = 0.560). CONCLUSIONS: Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Safety of Nonsteroidal Anti‐inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study
Date Crossref
20/10/2016
Éditeur
Wiley
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Sujets associés

Inflammatory mediators and NSAID effectsCancer, Stress, Anesthesia, and Immune ResponseEnhanced Recovery After Surgery

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