Elimination of Taenia solium Transmission in Northern Peru
Rattachement africain : pe, us, uy, gb, au. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Taeniasis and cysticercosis are major causes of seizures and epilepsy. Infection by the causative parasite Taenia solium requires transmission between humans and pigs. The disease is considered to be eradicable, but data on attempts at regional elimination are lacking. We conducted a three-phase control program in Tumbes, Peru, to determine whether regional elimination would be feasible. METHODS: We systematically tested and compared elimination strategies to show the feasibility of interrupting the transmission of T. solium infection in a region of highly endemic disease in Peru. In phase 1, we assessed the effectiveness and feasibility of six intervention strategies that involved screening of humans and pigs, antiparasitic treatment, prevention education, and pig replacement in 42 villages. In phase 2, we compared mass treatment with mass screening (each either with or without vaccination of pigs) in 17 villages. In phase 3, we implemented the final strategy of mass treatment of humans along with the mass treatment and vaccination of pigs in the entire rural region of Tumbes (107 villages comprising 81,170 people and 55,638 pigs). The effect of the intervention was measured after phases 2 and 3 with the use of detailed necropsy to detect pigs with live, nondegenerated cysts capable of causing new infection. The necropsy sampling was weighted in that we preferentially included more samples from seropositive pigs than from seronegative pigs. RESULTS: Only two of the strategies implemented in phase 1 resulted in limited control over the transmission of T. solium infection, which highlighted the need to intensify the subsequent strategies. After the strategies in phase 2 were implemented, no cyst that was capable of further transmission of T. solium infection was found among 658 sampled pigs. One year later, without further intervention, 7 of 310 sampled pigs had live, nondegenerated cysts, but no infected pig was found in 11 of 17 villages, including all the villages in which mass antiparasitic treatment plus vaccination was implemented. After the final strategy was implemented in phase 3, a total of 3 of 342 pigs had live, nondegenerated cysts, but no infected pig was found in 105 of 107 villages. CONCLUSIONS: We showed that the transmission of T. solium infection was interrupted on a regional scale in a highly endemic region in Peru. (Funded by the Bill and Melinda Gates Foundation and others.).
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Elimination of <i>Taenia solium</i> Transmission in Northern Peru
- Date Crossref
- 16/06/2016
- Éditeur
- Massachusetts Medical Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidad Peruana Cayetano Heredia pays non établi dans la noticeUniversité ou école supérieure
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Center for Global Health pays non établi dans la noticeOrganisme public
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Instituto Nacional de Ciencias Neurológicas Cysticercosis Unit pays non établi dans la noticeÉtablissement de santé
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National University of San Marcos pays non établi dans la noticeUniversité ou école supérieure
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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Georgia State University Centers for Disease Control and Prevention pays non établi dans la noticeUniversité ou école supérieure
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National Center for Infectious Diseases pays non établi dans la noticeStructure de recherche
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Division of Parasitic Diseases and Malaria pays non établi dans la noticeStructure de recherche
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Portland State University pays non établi dans la noticeUniversité ou école supérieure
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Oregon Health & Science University pays non établi dans la noticeUniversité ou école supérieure
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Inter-American Institute pays non établi dans la noticeOrganisme public
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University of Salford pays non établi dans la noticeUniversité ou école supérieure
Universidad Peruana Cayetano Heredia, Center for Global Health et Cysticercosis Unit — Instituto Nacional de Ciencias Neurológicas, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.