Expression of CXCR4 in osteosarcoma and its clinical implication
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Le résumé fourni par la source
Objective To investigate the expression of chemokine( C-X-C motif) receptor 4( CXCR4) in human osteosarcoma tissue and its clinical implication. Methods Total 86 cases of osteosarcoma tissues obtained by surgical resection and confirmed by pathological examination. The expression levels of CXCR4 in these tissues were examed by immunohistochemical staining. It correlation with the gender,pathology type,histology grade and tumor metastasis was analyzed. Results The expression of CXCR4 was positive in 43 cases( 50%),there was no difference between genders,pathology types of same histology grade. While higher expression rates were seen in the higher grade or metastasis tissues with a statistical significance( P 0. 05),and the positively expression rate also related with Enneking grading( P 0. 05). Conclusion CXCR4 might indicate the histology grade and predict metastasis of osteosarcoma.
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Où se fait cette recherche
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Tongji Hospital Department of Orthopedics pays non établi dans la noticeÉtablissement de santé
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
Department of Orthopedics — Tongji Hospital et Huazhong University of Science and Technology.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.