2015
article
No Perinatal HIV-1 Transmission From Women With Effective Antiretroviral Therapy Starting Before Conception
Laurent Mandelbrot, Roland Tubiana, Jerome Le Chenadec, Catherine Dollfus, Albert Faye, Emmanuelle Pannier, Sophie Matheron, Marie-Aude Khuong, Valerie Garrait, Veronique Reliquet, Alain Berrébi, C Allisy, Christophe Elleau, Cedric Arvieux, Christine Rouzioux, Josiane Warszawski, Stéphane Blanche, for the ANRS-EPF Study Group, Catherine Crenn‐Hébert, Corinne Floch-Tudal, Fabienne Mazy, Marine Joras, Françoise Meier, Emmanuel Mortier, Pierre‐François Ceccaldi, Maïa Banigé, Agnès Uludag, Virginie Zarouk, A. Lefort, Gilles Hittinger, Jean-Marc Chamouilli, Christian Burle, Alain Lafeuillade, Marie Medus, Germaine Bachelard, Joëlle Dendale-Nguyen, Thomas Guimard, Karine Guimard, Jean-Pierre Brossier, Philippe Van de Perre, Jean-Luc Esnault, Olivier Bollengier Stragier, Sophie Leautez-Nainville, Sandrine-Anne Martha, Benoît Martha, E. Maurel, Michel Françoise, Muriel Barat, Patricia Murger, Mahfoud Rouha, P Lumbroso, A Checoury, Pascale Perfezou, Gilles Blondin, Séverine Ansart, Luc de Saint Martin, Philippe Le Moine, Corinne Daniel, Christian Calvez, Emmanuelle Boutard, Cédric Arvieux, Estelle Bauville, Christelle Dupre, Yves Poinsignon, Anne Grelier, Gaétane Mousset, Corinne Cudeville, Mathilde Niault, Isabelle Belzic, Philippe Moreau, Marie-Françoise Le Coz, Odile Luycx Vaillant, Virginie Vitrat, Didier Tardif, Jacques Gaillat, Anne Vanderbergh, Suzanne Braig, Marion Dehlinger-Paul, Khaled Mohamed, Brigitte Heller-Roussin, Cécile Winter, Ghislaine Firtion, Myriam Costa, Odile Launay, Dominique Salmon Ceron, Mandovi Rajguru, Neila Elaoun, Lahcene Allal, Élie Azria, Agnès Bourgeois Moine, Valérie Garrait, Isabelle Hau, Claudine Touboul, Lanto Ratsimbazafy, Christiane Kommé, Brigitte Elharrar, Jean-Marc Labaune, Laurent Cotte, R.-C. Rudigoz, Camille Runel-Belliard, Thierry Pistone, Blandine Muanza, E. Broustal, Marc Duval-Arnould, Bénédicte Carpentier, Etienne Dienga, Marialuisa Partisani, Natacha Entz‐Werlé, Éric David, David Rey, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, J Tricoire, Claudine Cayla, Anne Boutemy, Isabelle Metheron, Didier Armangaud, Sophie Couderc, Corinne Routier, Alain Alissa, E. Questiaux, Ahmed Zakaria, Hélène Dauphin, Céline Goissen, Marie Belloy, Jean-Luc Delassus, Christine Cheneau, Jean-Marie Lang, Dominique Brault, Marie-Gisèle Lebrette, Lise Selleret, François Hervé, Pascal Bolot, Marie-Aude Khuong-Josses, Dieudoné Ekoukou, Stéphane Bounan, Stéphane Blanche, Delphine Lemercier, Pierre Frange, Florence Veber, Alain Devidas, Michèle Granier, Rose Nguyen, Adrien May, Amélie Chabrol, Pierre Chevojon, Zaitoun Abdallah Moussa, Claire Pluchart, Christine Rouger, Manuela Bonmarchand, Luminata Shneider, Fabienne Caby, Ruxandra-Oana Calin, Anne Coursol, V. Chambrin, Philippe Labrune, Laure Clech, Isolde Pauly-Ravelly, Raghad Moalim, Lydie Sanchez, Ama Johnson, Eric Lachassine, L. Benoist, Vincent Jeantils, J. Gaudelus, Amélie Benbara, Anne Borgne, Leïla Karaoui, Véronique Lefevre Elbert, A. Bongain, Fabrice Monpoux, Anne Deville, Eliane Galiba, Antoine Doumet, Jean-Luc Schmidt, L. Cravello, Claire Hubert, Marie-Dominique Tabone, Mary‐France Courcoux, G. Leverger, B. Carbonne, Didier Pinquier, Brigitte Clavier, Gaëlle Pinto-Cardoso, Martine Lévine, Erianna Bellaton Marouts, Constance Borie, C. Boissinot, Delphine Peretti, Corinne Fourcade, Catherine Chirouze, Cécile Brunet-Cartier, Véronique Reliquet, Cécile Brunet-Cartier, Norbert Winer, Edouard Vaucel, Claire Briandet, Jacques Brouard, A. Chalvon Demersay, Véronique Hentgen, Fabienne Messaoudi, Louis Bernard, Zoha Maakroun, Pascale Nau, Kamila Kébaïli, Kareen Billiemaz, Ramona Abrudan, Pascale Fialaire, Loïc Sentilhes, Stéphanie Proust, Philippe Arsac, Louis Mesnard, Evelyne Werner, N Ciraru‐Vigneron, G Mouchnino, D Ayral, Emmanuelle Vintejoux, Muriel Lalande, Jacques Reynes, Michel Segondy, Christiane De Gennes, Cyril Clavel, Françoise Mazingue, Yamina Hammou, Faïza Ajana, Yves Hatchuel, Imad Nahri, Claire Genet, Sophie Ducroix-Roubert, Yves Aubrard, Anne Constanty, P. Weinbreck, Emilie Piet, Françoise Jacquier, Christophe Michau, Hassan Safwan, A. Boutet, Mohamed Abdelhadi, Narcisse Elenga, Sandrine Delmas, Jérôme Le Chenadec, Anais Perilhou, Christine Rouzioux, Jeanne Sibiude, Josiane Warszawski
311Citations signalées, ce qui n’est pas une note de qualité
29Institutions déclarées
2Pays d’affiliation déclarés
Rattachement africain : fr, us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The efficacy of preventing perinatal transmission (PT) of human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. The objective of this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential to eliminate PT. METHODS: A total of 8075 HIV-infected mother/infant pairs included from 2000 to 2011 in the national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ART, delivered live-born children with determined HIV infection status, and did not breastfeed. PT was analyzed according to maternal VL at delivery and timing of ART initiation. RESULTS: The overall rate of PT was 0.7% (56 of 8075). No transmission occurred among 2651 infants born to women who were receiving ART before conception, continued ART throughout the pregnancy, and delivered with a plasma VL <50 copies/mL (upper 95% confidence interval [CI], 0.1%). VL and timing of ART initiation were independently associated with PT in logistic regression. Regardless of VL, the PT rate increased from 0.2% (6 of 3505) for women starting ART before conception to 0.4% (3 of 709), 0.9% (24 of 2810), and 2.2% (23 of 1051) for those starting during the first, second, or third trimester (P < .001). Regardless of when ART was initiated, the PT rate was higher for women with VLs of 50-400 copies/mL near delivery than for those with <50 copies/mL (adjusted odds ratio, 4.0; 95% CI, 1.9-8.2). CONCLUSIONS: Perinatal HIV-1 transmission is virtually zero in mothers who start ART before conception and maintain suppression of plasma VL.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- No Perinatal HIV-1 Transmission From Women With Effective Antiretroviral Therapy Starting Before Conception
- Date Crossref
- 21/07/2015
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
HIV/AIDS Research and InterventionsHIV Research and TreatmentHIV/AIDS drug development and treatment