Neurocysticercosis as a Cause of Epilepsy and Seizures in Two Community-Based Studies in a Cysticercosis-Endemic Region in Peru
Rattachement africain : pe, us, fr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The prevalence of epilepsy added to inadequate treatment results in chronic morbidity and considerable mortality in poor populations. Neurocysticercosis (NCC), a helminthic disease of the central nervous system, is a leading cause of seizures and epilepsy in most of the world. METHODS: Taking advantage of a cysticercosis elimination program, we performed two community-based cross-sectional studies between 2006 and 2007 in 58 rural communities (population 20,610) to assess the prevalence and characteristics of epilepsy and epileptic seizures in this endemic region. Serological and computed tomography (CT) data in individuals with epilepsy were compared to previous surveys in general population from the same region. PRINCIPAL FINDINGS: In two surveys, 17,450 individuals were evaluated. Lifetime prevalence of epilepsy was 17.25/1000, and prevalence of active epilepsy was 10.8/1000 inhabitants. The prevalence of epilepsy increased after age 25 years and dropped after age 45. Only 24% (45/188) of patients with active epilepsy were taking antiepileptic drugs, all at sub-therapeutic doses. Antibodies to cysticercosis were found in approximately 40% of individuals with epilepsy in both studies. In one survey only individuals presenting strong antibody reactions were significantly associated with having epilepsy (OR 5.74; p<0.001). In the second, the seroprevalence as well as the proportion presenting strong antibody reactions were both significantly higher in individuals with epilepsy (OR 2.2 and 4.33, respectively). Brain CT showed NCC-compatible images in 109/282 individuals with epilepsy (39%). All individuals with viable parasites on CT were seropositive. CONCLUSION: The prevalence of epilepsy in this cysticercosis endemic region is high and NCC is an important contributor to it.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neurocysticercosis as a Cause of Epilepsy and Seizures in Two Community-Based Studies in a Cysticercosis-Endemic Region in Peru
- Date Crossref
- 13/02/2014
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universidad Peruana Cayetano Heredia pays non établi dans la noticeUniversité ou école supérieure
-
Center for Global Health pays non établi dans la noticeOrganisme public
-
Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
-
United States Naval Medical Research Unit SOUTH pays non établi dans la noticeÉtablissement de santé
-
Université de Limoges pays non établi dans la noticeUniversité ou école supérieure
-
Georgia State University pays non établi dans la noticeUniversité ou école supérieure
-
National University of San Marcos pays non établi dans la noticeUniversité ou école supérieure
-
Bloomberg School of Public Health Department of International Health pays non établi dans la noticeUniversité ou école supérieure
-
DIDE - Department of Infectious Disease Epidemiology [London] (South Kensington Campus pays non établi dans la noticeInstitution
-
U.S. Naval Medical Research Unit No. 6 pays non établi dans la noticeStructure de recherche
-
U.S. Naval Medical Research (Unit N°6 Lima - Pérou) pays non établi dans la noticeInstitution
-
Instituto de Ciencias Neurológicas pays non établi dans la noticeStructure de recherche
Universidad Peruana Cayetano Heredia, Center for Global Health et Johns Hopkins University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.