Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995–2006
Rattachement africain : fi, se. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: The number of children born after frozen embryo transfer (FET) is steadily rising. However, studies on obstetric and perinatal outcomes are limited. Our primary aim was to compare the perinatal health of children born after FET and fresh embryo transfer, and to use data from children born after spontaneous conception as a reference. METHODS: In a register-based cohort study we evaluated the obstetric and perinatal outcomes of children born after FET (n = 2293), fresh embryo transfer (n = 4151) and those born after spontaneous pregnancy (reference group; n = 31 946). Data were collected from the registers of two infertility outpatient clinics, two university hospitals and the Finnish Medical Birth Register (1995-2006). RESULTS: After adjusting for confounding factors the FET group showed decreased risks of preterm birth [adjusted odd ratio (AOR) 0.83, 95% confidence interval (CI) 0.71-0.97], low birthweight (AOR 0.74; 0.62-0.88) and being small for gestational age (AOR 0.63; 0.49-0.83) compared with the fresh embryo transfer group. Mean birthweight was 134 g higher in the FET singletons versus the fresh embryo transfer singletons (P< 0.0001). When FET singletons were compared with the reference group, increased risks of preterm birth (AOR 1.45; 1.25-1.68) and low birthweight (AOR 1.22; 1.03-1.45) and a decreased risk of being small for gestational age (AOR 0.71; 0.54-0.92) were found. No excess of perinatal and infant mortality occurred between the groups. CONCLUSIONS: Embryo freezing does not adversely affect perinatal outcome in terms of prematurity, low birthweight and being small for gestational age versus the fresh embryo transfer and the outcome is similar or even better, particularly regarding fetal growth. Our study, which is one of the largest on FET pregnancies, provides further evidence on the safety of FET.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Perinatal outcome of children born after frozen and fresh embryo transfer: the Finnish cohort study 1995–2006
- Date Crossref
- 02/02/2010
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Oulu University Hospital Department of Obstetrics and Gynecology pays non établi dans la noticeÉtablissement de santé
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Väestöliitto pays non établi dans la noticeOrganisation à but non lucratif
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Finnish Institute for Health and Welfare pays non établi dans la noticeOrganisme public
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Nordic School of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Helsinki University Hospital pays non établi dans la noticeÉtablissement de santé
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THL National Institute for Health and Welfare pays non établi dans la noticeStructure de recherche
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Helsinki University Central Hospital Department of Obstetrics and Gynecology pays non établi dans la noticeUniversité ou école supérieure
Department of Obstetrics and Gynecology — Oulu University Hospital, Väestöliitto et Finnish Institute for Health and Welfare, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.