Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy
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Le résumé fourni par la source
OBJECTIVE: To describe factors associated with neurocognitive (NC) function in HIV-positive patients on stable combination antiretroviral therapy. DESIGN: We undertook a cross-sectional analysis assessing NC data obtained at baseline in patients entering the Protease-Inhibitor-Monotherapy-Versus-Ongoing-Triple therapy (PIVOT) trial. MAIN OUTCOME MEASURE: NC testing comprised of 5 domains. Raw results were z-transformed using standard and demographically adjusted normative datasets (ND). Global z-scores (NPZ-5) were derived from averaging the 5 domains and percentage of subjects with test scores >1 standard deviation (SD) below population means in at least two domains (abnormal Frascati score) calculated. Patient characteristics associated with NC results were assessed using multivariable linear regression. RESULTS: Of the 587 patients in PIVOT, 557 had full NC results and were included. 77% were male, 68% Caucasian and 28% of Black ethnicity. Mean (SD) baseline and nadir CD4+ lymphocyte counts were 553(217) and 177(117) cells/µL, respectively, and HIV RNA was <50 copies/mL in all. Median (IQR) NPZ-5 score was -0.5 (-1.2/-0) overall, and -0.3 (-0.7/0.1) and -1.4 (-2/-0.8) in subjects of Caucasian and Black ethnicity, respectively. Abnormal Frascati scores using the standard-ND were observed in 51%, 38%, and 81%, respectively, of subjects overall, Caucasian and Black ethnicity (p<0.001), but in 62% and 69% of Caucasian and Black subjects using demographically adjusted-ND (p = 0.20). In the multivariate analysis, only Black ethnicity was associated with poorer NPZ-5 scores (P<0.001). CONCLUSIONS: In this large group of HIV-infected subjects with viral load suppression, ethnicity but not HIV-disease factors is closely associated with NC results. The prevalence of abnormal results is highly dependent on control datasets utilised. TRIAL REGISTRY: ClinicalTrials.gov, NCT01230580.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neurocognitive Function in HIV Infected Patients on Antiretroviral Therapy
- Date Crossref
- 30/04/2013
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Imperial College Healthcare NHS Trust Department of HIV and GU Medicine pays non établi dans la noticeÉtablissement de santé
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St Mary's Hospital pays non établi dans la noticeÉtablissement de santé
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Imperial College London Division of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University College London Centre for Sexual Health and HIV Research pays non établi dans la noticeUniversité ou école supérieure
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Medical Research Council pays non établi dans la noticeOrganisme public
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University Hospitals Sussex NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Brighton and Sussex University Hospitals NHS Trust pays non établi dans la noticeÉtablissement de santé
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Barts Health NHS Trust pays non établi dans la noticeÉtablissement de santé
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Royal London Hospital Ambrose King Centre pays non établi dans la noticeÉtablissement de santé
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East Sussex Healthcare NHS Trust pays non établi dans la noticeÉtablissement de santé
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Gloucestershire Royal Hospital Hope House pays non établi dans la noticeÉtablissement de santé
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Ealing Hospital Pasteur Suite pays non établi dans la noticeÉtablissement de santé
Department of HIV and GU Medicine — Imperial College Healthcare NHS Trust, St Mary's Hospital et Division of Medicine — Imperial College London, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.