Muscle Strength and BMI as Predictors of Major Mobility Disability in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P)
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Le résumé fourni par la source
BACKGROUND: Muscle weakness and obesity are two significant threats to mobility facing the increasing number of older adults. To date, there are no studies that have examined the association of strength and body mass index (BMI) on event rates on a widely used performance measure of major mobility disability. METHODS: This study was a secondary analysis of a randomized controlled trial in which sedentary functionally limited participants (70-89 years, Short Physical Performance Battery ≤ 9) who were able to complete a 400-m walk test at baseline were randomized to a physical activity or health education intervention and reassessed for major mobility disability every 6 months for up to 18 months. We evaluated whether baseline grip strength and BMI predicted failure to complete the 400-m walk test in 15 minutes or less (major mobility disability). RESULTS: Among N = 406 participants with baseline measures, lower grip strength was associated with an increased risk for developing major mobility disability, with and without covariate adjustment (p < .01): The hazard ratio (95% confidence interval) for the lowest versus high sex-specific quartile of grip strength was 6.11 (2.24-16.66). We observed a U-shaped relationship between baseline BMI and the risk of developing major mobility disability, such that the risk for participants with a BMI of 25-29 kg/m(2) was approximately half that of participants with BMI less than 25 or 30 kg/m(2) or more (p = .04 in fully adjusted analyses). CONCLUSIONS: Our data highlight the importance of muscle weakness, low BMI, and obesity as risk factors for major mobility disability in older adults. Being overweight may be protective for major mobility disability.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Muscle Strength and BMI as Predictors of Major Mobility Disability in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P)
- Date Crossref
- 05/10/2011
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wake Forest University Department of Health and Exercise Science pays non établi dans la noticeUniversité ou école supérieure
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Pennington Biomedical Research Center pays non établi dans la noticeStructure de recherche
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Tufts University and Sarcopenia Laboratory pays non établi dans la noticeUniversité ou école supérieure
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Jean Mayer Human Nutrition Research Center on Aging pays non établi dans la noticeOrganisme public
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Yale University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Maryland Department of Epidemiology and Public Health pays non établi dans la noticeUniversité ou école supérieure
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University of Pittsburgh pays non établi dans la noticeUniversité ou école supérieure
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University of Florida Department of Aging and Geriatric Research pays non établi dans la noticeUniversité ou école supérieure
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Institute on Aging pays non établi dans la noticeOrganisation à but non lucratif
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Wake Forest School of Medicine Department of Biostatistical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Epidemiology pays non établi dans la noticeInstitution
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Graduate School of Public Health Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Health and Exercise Science — Wake Forest University, Pennington Biomedical Research Center et and Sarcopenia Laboratory — Tufts University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.