Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone
Rattachement africain : au, gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The effect of sepsis on liver synthesis of albumin remains controversial, with studies in man suggesting that synthesis increases, whereas in animals increased, decreased and unaltered synthesis have been reported. To reconcile these conflicting data, total and relative albumin synthesis was measured in rats 24 h after caecal ligation and puncture (CLP) by immunoprecipitation of albumin following a flooding dose of L-[4-3H]phenylalanine. Following CLP, animals were starved for 18 h and then received intravenous infusions of saline or parenteral nutrition (PN) with or without glutamine for 6 h. In animals receiving PN, parenteral injections of growth hormone (GH) or saline vehicle were also administered. Fractional rate of liver total protein synthesis was elevated and total albumin synthesis rate was reduced in all CLP groups when compared with non-operated animals. Total albumin synthesis was also lower in all animals receiving PN than those receiving saline alone, although these differences did not attain statistical significance, except for the group receiving PN+GH. Relative albumin synthesis was also reduced after CLP, and was significantly lower in animals receiving PN than in those receiving saline alone. These findings suggest that in sepsis hepatic protein synthesis is reprioritized away from the production of albumin towards the production of acute-phase proteins and that this change is not influenced by the provision of nutritional support, glutamine or the administration of GH.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Liver albumin synthesis in sepsis in the rat: influence of parenteral nutrition, glutamine and growth hormone
- Date Crossref
- 01/12/2003
- Éditeur
- Portland Press Ltd.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
St George Hospital Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
-
King's College London Department of Nutrition and Dietetics pays non établi dans la noticeUniversité ou école supérieure
-
King's College School pays non établi dans la noticeUniversité ou école supérieure
-
Derriford Hospital Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
-
St Bartholomew's Hospital Department of Intensive Care pays non établi dans la noticeÉtablissement de santé
-
Stony Brook University pays non établi dans la noticeUniversité ou école supérieure
-
State University of New York at Stony Brook Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
Department of Intensive Care — St George Hospital, Department of Nutrition and Dietetics — King's College London et King's College School, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.