Urinary Prostaglandin D Synthase (β-Trace) Excretion Increases in the Early Stage of Diabetes mellitus
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: Circulating levels of lipocalin-type prostaglandin D synthase (L-PGDS)/beta-trace reportedly increase in renal failure as well as in cardiovascular injuries. We investigated the alterations of L-PGDS in urine and plasma in the early stage of type-2 diabetic patients. METHOD: Thirty-six type-2 diabetic patients and 29 normal subjects were studied. Overnight spot urine and plasma samples were obtained in the morning. L-PGDS was measured by ELISA method using anti-L-PGDS antibody. Variables indicating renal function were determined. RESULTS: Plasma L-PGDS concentration was slightly higher in the patients with diabetes mellitus than in the control subjects, whereas the urinary L-PGDS excretion almost doubled in the diabetic patients as compared with that in the control subjects. Plasma L-PGDS was determined by plasma creatinine (Cr) concentration while urinary L-PGDS excretion was correlated solely with urinary protein excretion. There was no relationship between plasma L-PGDS concentration and urinary L-PGDS excretion. The averaged plasma concentration of L-PGDS in the diabetics with a normal Cr level in plasma, corresponding to that in the controls, was determined by the plasma Cr concentration. On the other hand, the urinary L-PGDS excretion was determined by the amount of proteinuria and greater in the diabetics with a normal Cr level in plasma than in the controls even when the patients exhibited urinary protein excretion equal to that in the control subjects. CONCLUSIONS: Urinary L-PGDS excretion increased in the early stage of kidney injury in patients with type-2 diabetes mellitus. The urinary excretion was correlated independently with urinary protein excretion even when there was no difference in urinary protein or albumin excretions, thereby suggesting that urinary L-PGDS excretion is possibly a more sensitive indicator of renal injuries than proteinuria. Urinary L-PGDS may thus predict the progression of renal injuries in diabetic patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Urinary Prostaglandin D Synthase (β-Trace) Excretion Increases in the Early Stage of Diabetes mellitus
- Date Crossref
- 01/01/2001
- Éditeur
- S. Karger AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Tokyo Health Sciences Health Service Center and Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Yokohama City University pays non établi dans la noticeUniversité ou école supérieure
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The University of Tokyo pays non établi dans la noticeUniversité ou école supérieure
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NTT Medical Center pays non établi dans la noticeÉtablissement de santé
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Mitsui (Japan) pays non établi dans la noticeEntreprise
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Mita Hospital pays non établi dans la noticeÉtablissement de santé
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Tokyo Metropolitan Police Hospital pays non établi dans la noticeÉtablissement de santé
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Japan Science and Technology Agency pays non établi dans la noticeOrganisme public
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Kanto Medical Center NTT Departments of Nephrology and of Endocrinology and Metabolism pays non établi dans la noticeÉtablissement de santé
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Mitsui Hospital Health Service Center pays non établi dans la noticeÉtablissement de santé
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Tokyo Police Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Osaka Bioscience Institute Department of Molecular Behavioral Biology pays non établi dans la noticeStructure de recherche
Health Service Center and Department of Medicine — University of Tokyo Health Sciences, Yokohama City University et The University of Tokyo, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.