Clinical Indicators for Differential Diagnosis of Acute Lower Abdominal Pain in Women of Reproductive Age

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Background: Acute lower abdominal pain in women of reproductive age is a challenging condition for clinical diagnosis. Computerized tomography yields high accuracy, but may not be cost-effective in low-middle income countries. Selective diagnostic approach based on clinical findings may be more appropriate.  Methods: Medical record review was performed on patients aging between 15 - 50 years who admitted to the surgical department or obstetrics and gynecology (OB-GYN) unit because of acute lower abdominal pain during January to December 2008. Patients were eventually categorized into appendicitis, OB-GYN conditions, or non-specific abdominal pain (NSAP). Clinical indicators were studied for diagnostic values using polytomous logistic regression applied to likelihood ratio for positive test (LR + ) and confidence interval (CI).  Results: Anorexia, nausea and vomiting, shifting of abdominal pain decreased the likelihood of OB-GYN conditions. Diarrhea increased the likelihood of NSAP. Right lower quadrant tenderness increased the likelihood of appendicitis but decreased the likelihood of OB-GYN conditions. Left lower quadrant tenderness decreased the likelihood of appendicitis but increased the likelihood of OB-GYN. Guarding or rebound tenderness increased the likelihood of appendicitis but reduced the likelihood of NSAP. Leucocytosis (white blood cell count ≥ 10,000) increased the likelihood of appendicitis but reduced the likelihood of OB-GYN and NSAP. Neutrophil ≥ 75% increased the likelihood of OB-GYN but decreased the likelihood of NSAP. Pregnancy reduced the likelihood of appendicitis and increased the likelihood of OB-GYN.  Conclusion: Gastrointestinal symptoms, sites of abdominal tenderness, guarding or rebound tenderness, leucocytosis, neutrophil ≥ 75% and pregnancy are clinical indicators that may help differentiating appendicitis, common OB-GYN conditions, or NSAP in acute lower abdominal pain in women of reproductive age. doi: http://dx.doi.org/10.4021/jcs179w

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