Zhuhai Center for Disease Control and Prevention

Development of electrochemiluminescence immunochromatographic test strips for dengue virus

Qinyi Zhang, Yao Qin, Xihan Wang, Liting Xiao et autres

Introduction Dengue virus (DENV) infection poses a serious threat to global public health. Rapid and sensitive point-of-care diagnostic methods are urgently needed for early detection and epidemic control. Methods The dengue virus monoclonal antibody NS1-McAb1# was labeled as the labeled antibody and …

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An integrated multi-technique strategy for in vitro metabolite identification and profiling of gymnodimine A using LC-HRMS/MS

Jiangang Chen, Shuai Liu, Sudan Liang, Minglei Zhong et autres

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Social network analysis of geosocial networking among men who have sex with men in Zhuhai, China

Yuxin Han, Fengshi Jing, Zeyu Luo, Xi Zhang et autres

BACKGROUND: Social media platforms are important spaces for social and sexual networking among men who have sex with men (MSM). However, limited research has examined structural changes in MSM digital social networks or the contribution of different user roles in maintaining network …

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Construction of a public health emergency information system framework: A case study of Zhuhai city, China

Sicheng Huang, Xuebao Zhang, Long Chen, Xihe Ni et autres

BACKGROUND: A public health emergency information system serves as a critical tool for collecting and analyzing data from sudden public health events, thereby providing a scientific basis for governmental decision-making. However, research on the systematic construction of such information system frameworks within …

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Bioinformatics identification of copyback and multihost-adapted defective viral genomes in dengue virus

Jianhai Yu, Hao Wu, Yan Zhan, Yuan Liang et autres

Introduction Defective viral genomes (DVGs) have been detected in clinical samples, and their antiviral effects have been verified. However, due to the limitations of traditional methods, all the reported DENV DVGs to date are Deletion DVGs, and it has not been proven …

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Genomic and plasmid profiles of multidrug-resistant Salmonella isolates from pediatric patients from Zhuhai, China

Y Chen, Yanmei Fang, Kaisong Huang, Huitao Huang et autres

ABSTRACT Multidrug-resistant Salmonella has been classified as a pathogen of high priority. However, limited or mixed-quality studies reported multidrug-resistant Salmonella strains from pediatric patients. The study aimed to investigate the prevalence, serotypes, antimicrobial characteristics, and plasmid profiles of clinical Salmonella strains isolated …

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Integrated computational and experimental approaches for drug repurposing targeting key Mycobacterium tuberculosis proteins

Hongfu Li, Likun Zhao, Zixin Liu, Zhenzhen Du et autres

Mycobacterium tuberculosis ( Mtb ) remains one of the deadliest pathogens worldwide, further complicated by the increasing prevalence of multidrug-resistant (MDR) and extensively drug-resistant strains. In this study, a structure-based virtual screening workflow was employed to repurpose approved drugs from the DrugBank …

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Intergenerational transmission of adverse childhood experiences: Differential maternal and paternal associations with offspring mental health in Chinese school-aged children by multi-method

Mengna Wei, Baohua Zheng, Ting Ning, Zengzhen Zhang et autres

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Integrating computational and biological approaches for the discovery of putative MmpL3 inhibitors against Mycobacterium tuberculosis

Likun Zhao, Hongfu Li, Xiuling Ma, Jiahao Sun et autres

The rapid emergence of drug-resistant Mycobacterium tuberculosis strains has progressively undermined the efficacy of existing anti-tuberculosis therapies, underscoring the urgent need for new therapeutic agents. MmpL3, an essential transporter involved in mycobacterial cell wall biosynthesis, represents a promising drug target. In this …

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Evaluating peer navigation in promoting digital secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a two-arm randomized controlled trial

Hao Ren, Fengshi Jing, Xinyuan Zhang, Siyue Hu et autres

BACKGROUND: In China, the HIV prevalence among men who have sex with men (MSM) is still rising, with a large proportion of people never tested for HIV in this group. HIV self-testing (HIVST) offers a user-empowered approach in expanding testing coverage. Peer …

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[Bibliometric analysis on complex network techniques in HIV preventive interventions].

S L Xie, F S Jing, C C He, R Y Li et autres

From 2015 to 2024, research on complex network technologies in HIV preventive interventions showed overall growth, with a predominant focus on original research. Knowledge production and collaboration displayed significant centralization and a "core-periphery" pattern. Cross-disciplinary collaboration has driven intelligent methods to become …

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Vaccination Coverage, Timeliness and Adverse Events Following Immunization in Children with Medical Conditions — Shandong Province, China, 2023

Song Yudan, Xiang Zeng, Liu Shaonan, Wang Yan et autres

What is already known about this topic?: Children with medical conditions who remain undervaccinated are at risk of vaccine-preventable diseases. What is added by this report?: In a multicenter retrospective study of 24,966 children with medical conditions, the median coverage of 10 …

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