Evolution et ingénierie de systèmes dynamiques

Proteome-wide prediction of the functional impact of missense variants with ProteoCast

Marina Abakarova, María Inés Freiberger, Arnaud Liehrmann, Michaël Rera et autres

Abstract Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying therapeutic targets. Despite progress in sequencing and genome editing technologies, proteome-wide mutation effect prediction remains challenging. Here we show that evolutionary information alone …

fr (code pays fourni par la source)

Protein and genomic language models uncover the unexplored diversity of bacterial immunity

Ernest Mordret, Alexandre Hervé, Florian Tesson, Hugo Vaysset et autres

The bacterial pangenome contains a vast diversity of antiphage systems, whose overall extent is still unknown. In this study, we developed complementary machine learning approaches to systematically predict antiphage function from genomic context, protein sequence, or their combination, achieving up to 99% …

fr (code pays fourni par la source)

Qualitative insights into the experiences of French parents of children with developmental coordination disorder (DCD): Child-related challenges and family implications

Léa Chawki, Jessica Letot, Johanna Despax, Caroline Huron et autres

Parents of children with developmental coordination disorder (DCD) are at high risk of having their well-being negatively impacted (e.g., stress, quality of life, anxiety, and depression). However, no study has specifically explored the experience of French parents of children with DCD despite …

fr (code pays fourni par la source)

ProteoCast: a web server to predict, validate, and interpret missense variant effects

Marina Abakarova, María Inés Freiberger, Arnaud Liehrmann, Michael Rera et autres

Understanding how mutations affect protein function remains critical yet challenging, particularly for variants in clinical databases lacking experimental characterisation and for intrinsically disordered regions. Current computational approaches often operate as black boxes, providing predictions without sufficient transparency or quality assessment of the …

fr (code pays fourni par la source)

Multilayer Louvain: a modularity-based community detection algorithm for multilayer networks

Soumajit Pramanik, Prishni Rateria, Raphaël Tackx, Mayank Shukla et autres

in, fr (code pays fourni par la source)

ProteoCast: a web server to predict, validate, and interpret missense variant effects

Marina Abakarova, María Inés Freiberger, Arnaud Liehrmann, Michaël Rera et autres

Abstract Understanding how mutations affect protein function remains critical yet challenging, particularly for variants in clinical databases lacking experimental characterisation and for intrinsically disordered regions. Current computational approaches often operate as black boxes, providing predictions without sufficient transparency or quality assessment of …

fr (code pays fourni par la source)

Parental well-being among French parents of children with Developmental Coordination Disorder (DCD): A Cross-Sectional Study

Léa Chawki, Caroline Huron, Émilie Cappe

BACKGROUND: Parents of children with developmental coordination disorder (DCD) report increased burden, stress, and negative impacts on their mental health. However, there is limited research on the experiences and well-being of French parents raising children with DCD. AIMS: This study aimed to …

fr (code pays fourni par la source)

Open educational resources for distributed hands-on teaching in molecular biology

Ariel Cerda, Alejandro Aravena, Valentina Zapata, Aníbal Arce et autres

The urgent need to develop a more equitable bioeconomy has positioned biotechnology capacity building at the forefront of international priorities. However, in many educational institutions, particularly in low- and middle-income countries, this remains a major challenge due to limited access to reagents, …

cl, si, gb, fr, ar (code pays fourni par la source)

Demonstration of bioplastic production from CO2 and formate using the reductive glycine pathway in E. coli

Daria Fedorova, Roee Ben-Nissan, Eliya Milshtein, Cassandra Reyes et autres

There is a strong need to develop technologies that reduce anthropogenic pollution and the dependence on nonrenewable Earth resources. One way of doing so is by harnessing biological systems for replacing the production of fossil-fuel based goods with low-environmental-impact alternatives. Recently, progress …

fr, il, us, de (code pays fourni par la source)

MALIN : MAnuels scoLaires INclusifs

Élise Lincker, Léa Pacini, Mohamed Amine Lasheb, Olivier Pons et autres

National audience

fr (code pays fourni par la source)

qByte: An open-source isothermal fluorimeter for democratizing analysis of nucleic acids, proteins and cells

Francisco Quero, Guy Aidelberg, Hortense Vielfaure, Yann Huon de Kermadec et autres

Access to affordable and reliable scientific instrumentation remains a significant barrier to the democratization of healthcare and scientific research. In the field of biotechnology, in particular, the complexity, cost, and infrastructure requirements of many instruments continue to limit their accessibility, especially in …

fr, gb, cl, Ghana, ch (code pays fourni par la source)

Accurate and efficient data-driven psychiatric assessment using machine learning

Kseniia Konishcheva, Bennett L. Leventhal, Maki Koyama, Sambit Panda et autres

us, fr (code pays fourni par la source)