Sansure Biotech (China)

Comparative Effects of Different Sugar Substitutes in a Mice Model of Type 2 Diabetes Induced Renal Injury

Yilin Bian, Bin Wang, Sha Liu, Huaxue Huang et autres

ABSTRACT The global incidence of diabetic kidney disease (DKD) due to type 2 diabetes is rising and is becoming one of the most threatening complications. Excessive sugar intake accelerates DKD progression, highlighting safe, low‐calorie sugar substitutes as potential intervention. This study aimed …

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Fishing plasma-circulating autoantibodies with magnetic pseudo-platelets for rapid optomagnetic quantification

Qin Bi, Yulin Yang, Bing Tan, Bo Tian et autres

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Trimethylamine N-Oxide Combined with Phenylacetylglutamine as Potential Biomarkers for Diabetic Kidney Disease

G. L. Xiong, Qing Fang, Hao Wu, Di Zhang et autres

Purpose: For diabetic kidney disease (DKD), a serious complication of diabetes mellitus, this study was designed to assess the potential utility of two gut microbiota-derived metabolites — trimethylamine N-oxide (TMAO) and phenylacetylglutamine (PAGln) — individually and in combination for identifying DKD. Methods: …

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Comparative Pharmacokinetics and Bioequivalence Assessment of Metformin/Pioglitazone Tablet in Fasting and Fed Conditions: A Randomized Study in Healthy Chinese Subjects

Hongcheng Li, Mengke Li, Bin Liu, Zijie Wei et autres

Abstract Metformin/pioglitazone tablets are a fixed‐dose combination of metformin hydrochloride and pioglitazone. In healthy Chinese subjects, this study evaluated the pharmacokinetics and bioequivalence of metformin/pioglitazone (500/15 mg) tablets. We conducted a single‐center, open‐label, randomized, two‐way crossover study in which subjects were randomized …

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A liquid biopsy-based multi-methylation marker panel for minimally invasive gastric cancer screening

Fengying Long, Xu Yi, Kang Wu, Xiaoyu Fu et autres

BACKGROUND: Gastric cancer (GC) is the fifth most prevalent cancer and the fifth leading cause of cancer-related mortality worldwide. The current gold standard for clinical diagnosis is gastroscopy, which, despite its high sensitivity and specificity, is limited by its invasive nature and …

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Trimethyllysine as a potential biomarker for heart failure

Yuyan Lei, Qing Fang, Qingqi Wu, G. L. Xiong et autres

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Temperature-sensitive chlorophyll degradation uncouples degreening from other ripening traits and guides postharvest quality improvement in kiwifruit

Ameer Hamza Hafeez, Zheng Zhang, Ang Li, Zhebin Zeng et autres

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Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema

Wenqin Xiao, Yan Zhu, Xinjie Tang, Kongkai Zhu et autres

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AM‑DMF-Lib-prep: A clinical ready lib-prep-on-a-chip platform with active-matrix digital microfluidics

Hanbin Ma, Yue Wang, Bingbing Zhang, Tong Wang et autres

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Evaluation of a sensitive real-time PCR assay for Group B Streptococcus detection in vaginal-rectal swab

Xiaochen Wang, Nana Wang, Jiayi Wang, Sai Zhang et autres

Group B Streptococcus (GBS) is associated with invasive infections in newborns. The obstetric field requires a rapid method for obtaining GBS screening results. Our objective was to determine whether a sensitive real-time PCR assay demonstrates acceptable diagnostic performance. This study involved 301 …

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Advancing Daptomycin Precision Dosing Through Evaluation of Published Population Pharmacokinetic Models and Development of a Dosing Tool

Xi Xie, Cheng Qian, Sonia Luque, Li Liu et autres

Background: Daptomycin is an important antibiotic against multidrug-resistant Gram-positive infections, but its wide interindividual variability and narrow therapeutic window pose challenges for optimal dosing. Population pharmacokinetic (PopPK) models provide a quantitative framework for precision dosing, yet a systematic evaluation of existing models …

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Rapid square wave voltammetry assay for antibiotic susceptibility test using methylene blue as an extracellular electron transfer

Yuning Zhou, Kexin Zhang, Chun Xu, Yawen He et autres

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