Comparative Effects of Different Sugar Substitutes in a Mice Model of Type 2 Diabetes Induced Renal Injury
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Le résumé fourni par la source
ABSTRACT The global incidence of diabetic kidney disease (DKD) due to type 2 diabetes is rising and is becoming one of the most threatening complications. Excessive sugar intake accelerates DKD progression, highlighting safe, low‐calorie sugar substitutes as potential intervention. This study aimed to elucidate the effects of different sugar substitutes on DKD and explore their underlying mechanisms. We established a mouse model of DKD using a high‐fat diet and streptozotocin and systematically compared the effects of Mogroside V (MOG), stevioside (ST), sucralose (TGS), erythritol (ERT), and sucrose (SUC). DKD mice exhibited typical renal injury characteristics along with increased renal oxidative stress and inflammatory responses. MOG and ST interventions significantly improved insulin levels; reduced blood urea nitrogen, serum creatinine, and urinary microalbumin levels; restored renal tissue structure; and alleviated oxidative‐inflammatory damage in DKD mice. ERT and TGS also mitigated oxidative‐inflammatory damage but had weaker effects, whereas SUC failed to improve DKD. Combined metabolomics, quantitative polymerase chain reaction, and western blot analyses indicated that different sugar substitutes exert comprehensive metabolic protection by regulating glycerophospholipid metabolism, linoleic acid metabolism, AMPK, MAPK signaling pathways, and FcεRI signaling pathways. Specifically, MOG significantly alleviated oxidative stress and inflammatory responses in DKD mouse kidneys by suppressing the mRNA expression of Alox5 , Pla2g4 , Raf1 , Hras , Ma2pk1 , Mapk1 , and Cysltr1 , as well as p‐ERK and 5‐lipoxygenase protein expression. These findings provide scientific evidence supporting the nutritional value of sugar substitutes in DKD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparative Effects of Different Sugar Substitutes in a Mice Model of Type 2 Diabetes Induced Renal Injury
- Date Crossref
- 27/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hunan University pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Agriculture Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops pays non établi dans la noticeOrganisme public
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Ministry of Education pays non établi dans la noticeOrganisme public
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Hunan Agricultural University pays non établi dans la noticeUniversité ou école supérieure
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Sansure Biotech (China) pays non établi dans la noticeEntreprise
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State Key Laboratory of Tea Plant Germplasm Innovation and Resource Utilization Changsha Hunan China pays non établi dans la noticeStructure de recherche
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INC Changsha Hunan China Hunan Huacheng Biotech pays non établi dans la noticeEntreprise
Hunan University, Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops — Ministry of Agriculture et Ministry of Education, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.