AltheaDx (United States)

Cost-Effectiveness of a Pharmacogenetic Test to Guide Treatment for Major Depressive Disorder

Erik J. Groessl, Steven R. Tally, Naomi Hillery, Alejandra Maciel et autres

BACKGROUND: Recent clinical trials indicate that pharmacogenetic-guided treatment of major depressive disorder (MDD) results in higher treatment response rates by genetically matching patients to medications and avoiding a trial-and-error process. OBJECTIVE: To evaluate the cost-effectiveness of a pharmacogenetic test (IDGx) that has …

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Estimating cost savings of pharmacogenetic testing for depression in real-world clinical settings

Alejandra Maciel, Ali Cullors, Andrew A. Lukowiak, Jorge A. Garces

The burden of depression significantly impacts the patient, the health care system, and society, at large. Medication management guided by pharmacogenetics has been shown to increase therapeutic efficacy and improve symptoms in patients diagnosed with depression, but limited data are available on …

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Economic Evaluation of Implementing a Novel Pharmacogenomic Test (IDgenetix®) to Guide Treatment of Patients with Depression and/or Anxiety

Mehdi Najafzadeh, Jorge A. Garces, Alejandra Maciel

The response to therapeutics varies widely in patients with depression and anxiety, making selection of an optimal treatment choice challenging. IDgenetix ® , a novel pharmacogenomic test, has been shown to improve outcomes by predicting the likelihood of response to different psychotherapeutic …

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Improved efficacy with targeted pharmacogenetic-guided treatment of patients with depression and anxiety: A randomized clinical trial demonstrating clinical utility

Paul Bradley, Michael Shiekh, Vishaal Mehra, Keith W. Vrbicky et autres

The objective of this study was to evaluate the effect of pharmacogenetics-guided treatment on patients diagnosed with depression and/or anxiety, in a diverse set of clinical settings, as compared to the standard of care. The trial design followed a prospective, randomized, subject- …

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Correlation of FCGRT genomic structure with serum immunoglobulin, albumin and farletuzumab pharmacokinetics in patients with first relapsed ovarian cancer

Daniel John O'Shannessy, Katie Bendas, Charles Schweizer, Wenquan Wang et autres

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Clinical Impact of Pharmacogenetic-Guided Treatment for Patients Exhibiting Neuropsychiatric Disorders

Marilyn C. Olson, Alejandra Maciel, Jean Francois Gariepy, Ali Cullors et autres

Objective: Pharmacogenetic testing holds promise as a personalized medicine tool by permitting individualization of pharmacotherapy in accordance with genes influencing therapeutic response, side effects, and adverse events. The authors evaluated the effect on outcomes for patients diagnosed with neuropsychiatric disorders of pharmacogenetics …

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Contribution of Pharmacogenetic Testing to Modeled Medication Change Recommendations in a Long-Term Care Population with Polypharmacy

Elaine A. Sugarman, Ali Cullors, Joel Centeno, David M. Taylor

BACKGROUND: Among long-term care facility residents, polypharmacy is common, and often appropriate, given the need to treat multiple, complex, chronic conditions. Polypharmacy has, however, been associated with increased healthcare costs, adverse drug events, and drug interactions. The current study evaluates the potential …

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Initial assessment of the benefits of implementing pharmacogenetics into the medical management of patients in a long-term care facility

Juan‐Sebastian Saldivar, David M. Taylor, Elaine A. Sugarman, Ali Cullors et autres

The health care costs associated with prescription drugs are enormous, particularly in patients with polypharmacy (taking more than five prescription medications), and they continue to grow annually. The evolution of pharmacogenetics has provided clinicians with a valuable tool that allows for a …

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CYP2D6 copy number distribution in the US population

Michelle Beoris, Jean Amos Wilson, Jorge A. Garces, Andrew A. Lukowiak

The cytochrome P450 2D6 (CYP2D6) gene is perhaps the most well characterized gene involved in drug metabolism and is known to have both gene duplication and deletion variants that are inheritable and stable. In a set of over 30,000 deidentified clinical samples …

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Abstract A63: A stroma-based 15 gene profile for prostate cancer suggests increased DNA methylation and senescence in the stroma of patients with poor prognosis

Zhenyu Jia, Farah B. Rahmatpanah, Xin Chen, Waldemar Lernhardt et autres

Abstract Biomarkers are needed to address overtreatment that occurs for the majority of prostate cancer patients that would not die of the disease but receive radical treatment. Barriers to biomarker discover include the polyclonal/multifocal nature of prostate tumors and the cell-type heterogeneity …

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Generation of “Virtual” Control Groups for Single Arm Prostate Cancer Adjuvant Trials

Zhenyu Jia, Michael B. Lilly, James A. Koziol, Xin Chen et autres

It is difficult to construct a control group for trials of adjuvant therapy (Rx) of prostate cancer after radical prostatectomy (RP) due to ethical issues and patient acceptance. We utilized 8 curve-fitting models to estimate the time to 60%, 65%, … 95% …

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NGS-based targeted RNA sequencing for expression profiling and relative quantitation of specific gene isoforms and fusions in tumor-specific panels.

Gordon Vansant, Mark Andrew Landers, Lien Vo, Kahuku Oades et autres

11108 Background: Gene expression signatures have become a useful tool for the identification of tumor subtypes and response to specific therapies. Expression of tumor, metastatic and macrophage specific transcripts utilizing alternative promoters and transcriptional start sites can further characterize these tumors . …

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