A&G Pharmaceutical (United States)

Temporal Toxicodynamics of Lead Nitrate in African Catfish (Clarias gariepinus) Fingerlings: Behavioural responses, probit-derived toxicity thresholds and environmental risk characterization

Stephen Ncha Ochang, Kenneth Igbang Sunday

Lead contamination of freshwater ecosystems remains a major environmental challenge with serious implications for fish health, aquaculture production, and ecological sustainability. The present study evaluated the acute toxicodynamics of lead nitrate in African catfish (Clarias gariepinus) fingerlings through a 96-hour laboratory bioassay. …

Nigéria, us (code pays fourni par la source)

Physiological costs of combined cadmium and glyphosate exposure in sub-adult Clarias gariepinus: Evidence from endocrine, metabolic and renal biomarkers

Kenneth Igbang Sunday, Nsa Akiba Ayi

The increasing occurrence of heavy metals and herbicides in aquatic environments raises concern regarding their combined effects on organisms. This study evaluated the physiological responses of sub-adult Clarias gariepinus exposed to fixed-ratio cadmium chloride–glyphosate binary mixtures using endocrine, metabolic, renal, and hepatic …

Nigéria, us (code pays fourni par la source)

Expression of progranulin (GP88) protein appears as an independent prognostic factor for clinical progression in high-risk prostate cancer patients

Renata Dubrovska, Markus Eckstein, Rudolf Jung, Charis Kalogirou et autres

Prostate cancer (PCa), the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. A particularly aggressive group of PCa, where prognostic biomarkers are still needed, are clinically defined high-risk PCa. We had previously shown that …

de, ch, us (code pays fourni par la source)

Visceral Leishmaniasis–Leprosy Co-infection in a Patient Living with HIV: A Case Study

Ilafe El Machi, Hiba Lazrek, Taoufik Ben Houmich, Asmae Lamrani Hanchi et autres

Leprosy and visceral leishmaniasis are two chronic infectious diseases resulting from intracellular pathogens whose clinical expression is largely the result of host cell-mediated immunity. Yet the concomitant occurrence of them in patients living with HIV remains exceedingly rare. This gives substantial diagnostic …

us, Maroc (code pays fourni par la source)

Phase 1 first-in-human trial of AG01, a recombinant humanized monoclonal antibody to progranulin/glycoprotein 88 (GP88) to determine the safety, tolerability, pharmacokinetics, and preliminary antitumor activity in subjects with advanced solid tumor malignancies.

Katherine H. R. Tkaczuk, Katherine Ann Scilla, Gautam G. Rao, Yixing Jiang et autres

TPS2669 Background: Progranulin also called GP88/PGRN plays a major role as an autocrine growth & survival factor associated with resistance to standard of care (SOC) targeted and chemo therapies in several cancers including breast cancer (BC) & non-small cell lung carcinoma (NSCLC): …

us (code pays fourni par la source)

Effect of much and biochar on soil runoff, drainage and ET under different rainfall rate

Mariam Diop, Sory Sissoko, Ginette Dembélé

A two months experiment was carried out at the Department of Soil Sciences, the University of Ghana to study the effect of soil amendments and rainfall rate per hour to runoff, drainage and evaporation. The experiment design was 1 x 8 factorial …

Ghana, Mali, us (code pays fourni par la source)

Abstract 3168: Fully human anti-HER-2 antibodies to HER-2 domains distinct from trastuzumab as antibody drug conjugates for tumor growth inhibition

Ginette Serrero, Jianping Dong, Jun Hayashi

Abstract HER2 is a receptor overexpressed in several cancers with prognostic and predictive implications as it is associated with shorter disease-free and overall survivals, resistance to hormonal agents and increased risk of brain metastasis. Trastuzumab is a humanized anti-HER2 neutralizing monoclonal antibody …

us (code pays fourni par la source)

Abstract 5646: Fully human monoclonal antibodies for antibody drug conjugate development to a cell surface target expressed in cancers with unmet needs.

Ginette Serrero, Jorge Marquez, Jianping Dong, Jun Hayashi

Abstract The development of Antibody drug conjugates (ADCs) has shown to provide a powerful approach for the development of targeted therapies in Oncology. The majority of approved ADCs are focused on a few targets using a limited number of antibodies conjugated to …

us (code pays fourni par la source)

Histological evaluation of the effect of long-term exposure to lead acetate on the cerebellum of albino rats and the therapeutic effect of atropine sulfate

Rashid Khamees Shaban, Mahmoud Nofal Mustafa, Abbas Fadhil Khudhur

The aim of current study is to investigate the effects of long-term exposure to lead acetate on histological architecture of cerebellum in rat brains. 24 animals were used in the experiment, which distributed to 4 groups, group (G1) control group was administrated …

us, iq (code pays fourni par la source)

Investigation of the anti-dengue and platelet-enhancing potential of Cedrus deodara heart wood extract: In vitro and in vivo evaluation in a Hydroxyurea-induced thrombocytopenia model

Keshava Kyatanahalli Shekharappa, Ramesh Chakka, Parikshit Roychowdhury, Girish Bolakatti et autres

us, in (code pays fourni par la source)

Abstract PS5-09-03: Prospective longitudinal study of circulating serum progranulin (PGRN/GP88) levels and its association with tumor response to therapies in patients with metastatic breast cancer (MBC)

K. H. Tkaczuk, K. Hu, P. Y. Rosenblatt, Nancy S. Tait et autres

Abstract The ability to monitor response to therapy and disease progression in patients with metastatic breast cancer (MBC) is a major step in patient management. Sequential imaging remains the method of choice for the assessment of disease status and monitoring of disease …

us (code pays fourni par la source)

Bio-enhancement in mucoadhesive drug delivery systems: A review

Mucoadhesive drug-delivery systems (MDDS) are designed to adhere to mucosal tissues, enhancing both local and systemic drug absorption. The addition of bioenhancers agents that improve membrane permeability, inhibit metabolic degradation, or modulate efflux transporters addresses issues of low mucosal permeability and first-pass …

us (code pays fourni par la source)