Katherine H. R. Tkaczuk

Time-restricted eating to entrain circadian rhythms, increase physiological responsiveness, and prevent stressor-induced frailty: A pilot randomized controlled trial

Amber S. Kleckner, Carin L. Clingan, Shalet James, Odessa R. Addison et autres

INTRODUCTION: Treatments for advanced and metastatic cancer can cause fatigue and accelerate the progression to frailty, a condition that increases vulnerabilities to stressors. Time-restricted eating (TRE) entails consuming food within a defined time window every day. TRE may help strengthen circadian rhythms …

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Corrigendum to ‘Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform’ [Biomaterials 180 (2018) 18764]

Hai Wang, Pranay Agarwal, Yutong Liang, Jiangsheng Xu et autres

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Phase 1 first-in-human trial of AG01, a recombinant humanized monoclonal antibody to progranulin/glycoprotein 88 (GP88) to determine the safety, tolerability, pharmacokinetics, and preliminary antitumor activity in subjects with advanced solid tumor malignancies.

Katherine H. R. Tkaczuk, Katherine Ann Scilla, Gautam G. Rao, Yixing Jiang et autres

TPS2669 Background: Progranulin also called GP88/PGRN plays a major role as an autocrine growth & survival factor associated with resistance to standard of care (SOC) targeted and chemo therapies in several cancers including breast cancer (BC) & non-small cell lung carcinoma (NSCLC): …

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Achieving epidemiologically representative enrollment and social determinants of health in the phase III evERA Breast Cancer study (NCT05306340).

Gregory A. Vidal, Hope S. Rugo, Ricki Fairley, Valarie Worthy et autres

1572 Background: Clinical trials have historically under-enrolled patients (pts) from racial and ethnic minority groups, resulting in study populations that do not reflect the epidemiology of cancer in the United States (US), limiting generalizability of the findings. In parallel, social determinants of …

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A Phase II Trial to Evaluate the Safety and Immunogenicity of Two Doses of a Folate Receptor Alpha Vaccine in Patients with Triple-Negative Breast Cancer

Keith L. Knutson, Hala Abu‐Fares, Peter J. Keating, Matthew Stephen Block et autres

PURPOSE: CD4 T-cell immunity is associated with improved survival in patients with breast cancer. We previously reported a phase I trial evaluating a folate receptor alpha (FRα) vaccine administered with cyclophosphamide (CP), demonstrating excellent safety and immunogenicity. To simplify the vaccine strategy …

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Transcriptomic Profiles and Functional Correlates of Cancer‐Related Fatigue: A Cross‐Sectional Study in Women Undergoing Cancer Treatment

Amber S. Kleckner, Evelina Mocci, Carin L. Clingan, Shari M Youngblood et autres

Background and Objectives: Cancer‐related fatigue is a multifactorial condition that affects most people undergoing chemotherapy. To elucidate potential biological underpinnings of fatigue, this study tested correlations between patient‐reported fatigue and (1) functional measures and (2) transcriptomics of whole blood. Methods: Women undergoing …

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Abstract PO5-18-06: On-going phase 1A clinical trial of A01, a chimerized monoclonal antibody to Progranulin/Glycoprotein 88 (GP88) in patients with advanced malignancy

Katherine H. R. Tkaczuk, Paula Rosenblatt, Ranee Mehra, Katherine Ann Scilla et autres

Abstract Progranulin (PGRN/GP88) is an 88 kDa glycoprotein characterized by seven and a half double cysteine rich repeats which is the largest member of the granulin-epithelin protein family. PGRN/GP88 has been demonstrated as a biological driver of tumorigenesis, survival, and drug resistance …

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Cancer Pharmacology

Ashkan Emadi, Judith E. Karp, Edward A. Sausville, Molly Graveno et autres

Bioinspired One Cell Culture Isolates Highly Tumorigenic and Metastatic Cancer Stem Cells Capable of Multilineage Differentiation

Hai Wang, Pranay Agarwal, Bin Jiang, Samantha Stewart et autres

Adv. Sci. 2020, 7, 2000259 https://doi.org/10.1002/advs.202000259 In the originally published article, some figures in the Supporting Information were incorrect. In these figures, incorrect images were used by accident for the control conditions of 1% alginate hydrogel of Day 5 in Figure S3a, …

Abstract OT3-13-01: First in Human Study of AG01 a chimerized monoclonal antibody to Progranulin/Glycoprotein 88 (GP88)

Katherine H. R. Tkaczuk, Paula Rosenblatt, Ranee Mehra, Katherine Ann Scilla et autres

Abstract Progranulin (PGRN/GP88) is an 88 kDa glycoprotein characterized by seven and a half double cysteine rich repeats in the granulin-epithelin family. PGRN/GP88 is an autocrine biological driver of tumorigenesis, survival & drug resistance in several cancers including breast, ovarian, multiple myeloma, …

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In-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy

Wenquan Ou, Samantha Stewart, Alisa M. White, Elyahb Allie Kwizera et autres

Abstract Cancer immunotherapy that deploys the host’s immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i.e., immunologically cold) tumor microenvironment (TME). Here, we report an in-situ cryo-immune …

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Greatly Enhanced CTC Culture Enabled by Capturing CTC Heterogeneity Using a PEGylated PDMS–Titanium–Gold Electromicrofluidic Device with Glutathione-Controlled Gentle Cell Release

Elyahb Allie Kwizera, Wenquan Ou, So Jeong Lee, Samantha Stewart et autres

The circulating tumor cells (CTCs, the root cause of cancer metastasis and poor cancer prognosis) are very difficult to culture for scale-up in vitro, which has hampered their use in cancer research/prognosis and patient-specific therapeutic development. Herein, we report a robust electromicrofluidic …

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