Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study
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Le résumé fourni par la source
Background/Objectives: Sleep continuity is a key determinant of daytime functioning; however, accessible and well-tolerated interventions remain limited. We investigated whether Bacillus coagulans IDCC 1201 improves objective sleep continuity and subjective sleep quality in adults with sleep disturbance. Methods: In this 4-week, randomized, double-blind, placebo-controlled trial, 80 adults (aged 19–65 years) received B. coagulans IDCC 1201 (5.0 × 109 CFU/day) or a placebo; 78 participants completed the study. The primary endpoint was the change in polysomnography-derived sleep efficiency from baseline to week 4. Results: Compared with the placebo, B. coagulans IDCC 1201 significantly improved sleep efficiency (Δ +13.71 ± 21.14 vs. −0.15 ± 13.35%; p = 0.002) and increased sleep duration (total sleep time: Δ +49.56 ± 76.33 vs. −0.50 ± 48.02 min; p = 0.002), accompanied by reduced nocturnal wakefulness (wake after sleep onset: Δ −44.40 ± 72.32 vs. +1.88 ± 44.36 min; p = 0.003; and total wake time: Δ −12.28 ± 20.22 vs. +0.53 ± 12.32 min; p = 0.004). Sleep-stage distribution also favored B. coagulans IDCC 1201, with greater increases in stage 2 and REM duration compared with the placebo (between-group p = 0.008 and 0.032, respectively). Subjective sleep quality showed greater improvement with B. coagulans IDCC 1201 (Pittsburgh Sleep Quality Index change: Δ −3.67 ± 3.37 vs. −1.64 ± 2.83; p = 0.036), yielding lower week 4 scores (5.87 ± 2.26 vs. 8.28 ± 3.62; p = 0.001). No significant safety concerns were identified. Conclusions: These findings indicate that strain-defined probiotic could be used as a nutritional approach for sleep health, particularly for targeting sleep fragmentation and maintenance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Efficacy and Safety of Bacillus coagulans IDCC 1201 for Sleep Improvement in Adults with Sleep Disturbance: A Randomized, Double-Blind, Placebo-Controlled Polysomnographic Study
- Date Crossref
- 11/05/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ildong (South Korea) pays non établi dans la noticeEntreprise
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Catholic University of Korea Department of Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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Pukyong National University Department of Food Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Seoul Sleep Center pays non établi dans la noticeÉtablissement de santé
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Ildong Bioscience pays non établi dans la noticeOrganisation à but non lucratif
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Seoul Special Sleep Center pays non établi dans la noticeInstitution
Ildong (South Korea), Department of Biotechnology — Catholic University of Korea et Department of Food Science and Technology — Pukyong National University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.