QPS (Austria)

Exploration of structural optic nerve changes in mouse models of retinal and neuronal degeneration with optical coherence tomography

Georg Ladurner, Marco Augustin, Danielle J. Harper, Sybren Worm et autres

Abstract Purpose The optic nerve head (ONH) is a central feature of the retina, affected in many human ocular pathologies, yet it has remained underexplored in most mouse models of disease. We hypothesize that the analysis of the ONH can yield valuable …

at (code pays fourni par la source)

Water activity and sorption thermodynamics of H2O/[EMIM][MeSO3] and H2O/Betaine:Glycerol from experimental Vapor-Liquid Equilibrium data

Michael Wernhart, René Rieberer, Christoph Weinzettl, Marlene Kienberger et autres

ABSTRACT Absorption heat pumps (AHPs) are a valuable technology for efficiently utilizing waste heat, e.g. from industrial processes. The common working pair H 2 O/LiBr is favored due to the high latent heat of water and its low saturation pressures. However, LiBr …

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RAGnaroX: A Secure, Local-Hosted ChatOps Assistant Using Small Language Models

Benedikt Dornauer, Mircea-Cristian Racasan

This paper introduces RAGnaroX, a resource-efficient ChatOps assistant that operates entirely on commodity hardware. Unlike existing solutions that often rely on external providers such as Azure or OpenAI, RAGnaroX offers a fully auditable, on-premise stack implemented in Rust. Its architecture integrates modular …

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Network pharmacology-based discovery and experimental validation of novel drug repurposing candidates in Alzheimer’s Disease

Attila Jones, Tina Loeffler, Evan Wu, Vijay R. Varma et autres

Abstract Despite a growing body of evidence implicating genetic variants and proteins encoded by them with risk and pathogenesis of Alzheimer’s disease (AD), this knowledge has not been successfully translated into effective AD treatments. We integrated current genomic, transcriptomic and proteomic profiles …

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Identification of a novel Aβ(pGlu3-x) targeting pathway in Alzheimer’s disease

Steffen Roßner, Sarah Schrempel, Corinna Höfling, Charlotte Minister et autres

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RAG-DIVE: A Dynamic Approach for Multi-Turn Dialogue Evaluation in Retrieval-Augmented Generation

Lorenz Brehme, Benedikt Dornauer, Jan-Henrik Böttcher, Klaus Schmid et autres

Evaluating Retrieval-Augmented Generation (RAG) systems using static multi-turn datasets fails to capture the dynamic nature of real-world dialogues. Existing evaluation methods rely on predefined datasets, which restrict them to static, one-directional queries and limit their ability to capture the adaptive, context-dependent performance …

at, de (code pays fourni par la source)

Towards safe and sustainable ionic liquids: a critical outlook on industrial and pharmaceutical integration

Assya Bellaadem, Roland Kalb, Blaž Likozar, Filipa A. Vicente

An integrated assessment combining LCA, TEA, toxicity, and scalability provides a comprehensive evaluation of ionic liquids for industrial implementation.

si, us, at (code pays fourni par la source)

Kinetic and thermodynamic study of lignin extraction from wheat straw using distillable and reusable ionic liquids

Marcell anon, Edita Jasiukaitytė‐Grojzdek, Markus Damm, Blaž Likozar et autres

si, at (code pays fourni par la source)

Determination of physicochemical properties of hydrophilic natural deep eutectic solvents as potential sorption media in absorption heat pumps and sorption heat storage units

Christoph Weinzettl, Paul Demmelmayer, Lukas Pachernegg-Mair, Michael Wernhart et autres

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Ultrasensitive saliva-based detection of early Alzheimer’s disease biomarkers via nanoparticle-enhanced evanescent scattering microscopy

Caterina Dallari, Milana Kendrisic, Federica Fenizi Caria, Claudia Manzl et autres

Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disease, yet early diagnosis remains a major challenge. Current cerebrospinal fluid (CSF) assays are invasive and unsuitable for large-scale or repeated screening. Blood-based biomarkers have achieved sensitivities above 90%, but still face challenges …

be, at, it (code pays fourni par la source)

The effect of CysLTR1 inhibition on cells of the retinal neurovascular unit in 5xFAD Alzheimer mice

Daniela Mayr, Julia Preishuber‐Pflügl, Andreas Koller, Susanne Maria Migschitz et autres

Alzheimer´s disease (AD) is a multifactorial neurodegenerative disease that affects both the brain and the retina. Many cerebral-associated AD pathologies, including neuroinflammation and vascular changes, have been reported to manifest in the retina. Furthermore, the neurovascular unit (NVU), composed of vascular cells, …

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Comparative Investigation of the Retinal Phenotype of Three Mouse Models of Alzheimer's Disease With Optical Coherence Tomography

Danielle J. Harper, Lucas May, Sybren Worm, Yash Patel et autres

Purpose: Mouse models of Alzheimer's disease (AD) are designed to replicate a multitude of pathologies. However, a direct comparison between models is virtually impossible due to vastly differing data acquisition and image processing protocols. Based on the hypothesis that a well-defined experimental …

at (code pays fourni par la source)