IL-27 induces a cytotoxic state in CD4 + T cells distinct from the Th1 lineage
Maria Inês Matias, Rémi Marrocco, Kyle Magro, Leonardo D. Sanchez Solis et autres
Abstract CD4 + cytotoxic T lymphocytes (CD4-CTLs) are understudied immune mediators with ambiguous origins. Despite expressing RUNX3, granzyme B (GZMB), and perforin (PRF1), CD4-CTLs are frequently classified as Th1 extensions due to shared interferon-γ (IFNγ) and T-BET expression. Here, we identify interleukin-27 …
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bioRxiv (Cold Spring Harbor Laboratory)