Nanopore sequencing panel for saliva-based host pharmacogenomic screening in anti-tubercular therapy
Priyanka Yadav, Swarup A.V. Shah, Aishwarya S. Babu, Minal Paradkar et autres
Abstract Rationale Host genotypes can predict subtherapeutic anti-tubercular drug exposures and treatment-associated toxicities. Screening for these variants could enable personalized dosing, but scalable assays for second-line drugs are lacking. Objectives We developed a nanopore sequencing panel to detect host variants affecting anti-tuberculosis …
in, Afrique du Sud, us (code pays fourni par la source)
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medRxiv