Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies
L. Aguilar, Fernando González‐Ortiz, Henrik Zetterberg, Thomas K. Karikari et autres
ABSTRACT INTRODUCTION Biomarkers for monitoring disease activity and treatment response in peripheral neuropathies remain limited. Big tau, a high-molecular-weight isoform of tau, is predominantly expressed in the peripheral nervous system (PNS). We investigated serum levels of big tau, brain-derived tau (BD-tau), and …
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