Michael Chun-Hin Wong

Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans

Christin Treiber-Kleinke, Jana Madeleine Göller, Justin Liba, Michael Chun-Hin Wong et autres

Fluorinated amino acids profoundly perturb cellular physiology because they enter the proteome while differing from their natural counterparts in subtle but functionally important ways. Here we investigated how Escherichia coli adapts to the biosynthesis and proteome-wide incorporation of fluorinated tryptophans derived from …

Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans

Christin Treiber-Kleinke, Jana Madeleine Göller, Justin Liba, Michael Chun-Hin Wong et autres

, involved in DNA mismatch repair, allowed replication errors to accumulate, generating transient hypermutator states that accelerated evolutionary exploration but were not required for successful adaptation. Reconstruction experiments confirmed that loss of stringent response control and altered TrpRS function together increased fitness …

de, ca (code pays fourni par la source)