MaaT013 fecal microbiotherapy modulates key gastro-intestinal and immunological processes involved in GvHD pathogenesis in vitro and in vivo
Bastien Laperrousaz, Julie Reygner, Margaux De Seilhac, Antoine Sabourin et autres
The purpose of the study was to evaluate the mechanism of action of MaaT013 fecal microbiotherapy in GI-aGvHD. Here, we used multi-omics analyses in complementary in vitro and in vivo models.In an in vitro, inflammation-induced leaky- model, MaaT013-derived metabolites prevented barrier disruption.In …
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