Isoserine Improves Spatial Memory and Remodels Synaptic and Inflammatory Gene-Expression Programs in APP/PS1 Mice
Alessandra Saitta, Rossella Basilotta, Marika Lanza, Michele Scuruchi et autres
Synaptic dysfunction is a major contributor to cognitive decline in Alzheimer’s disease (AD) and represents an attractive therapeutic target. Here, we investigated whether chronic isoserine treatment improves cognition and alters the expression of synaptic-related genes in APP/PS1 mice. Isoserine was well tolerated …
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