Marika Lanza

Isoserine Improves Spatial Memory and Remodels Synaptic and Inflammatory Gene-Expression Programs in APP/PS1 Mice

Alessandra Saitta, Rossella Basilotta, Marika Lanza, Michele Scuruchi et autres

Synaptic dysfunction is a major contributor to cognitive decline in Alzheimer’s disease (AD) and represents an attractive therapeutic target. Here, we investigated whether chronic isoserine treatment improves cognition and alters the expression of synaptic-related genes in APP/PS1 mice. Isoserine was well tolerated …

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Troxerutin Activity Against Oxidative Stress: A Potential Strategy for Corneal Damage Evaluated in a 3D Model of Human Corneal Epithelial Cells

Rossella Basilotta, Alessia Filippone, Nicoletta Palermo, Giovanna Casili et autres

Background:Oxidative stress and inflammation are closely associated with ocular surface disorders, including dry eye disease (DED), keratitis, and corneal erosion. These pathological processes contribute to an imbalance in tear composition and induce structural and functional alterations of the cornea. In this context, …

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Correction: Filippone et al. Inhibition of LRRK2 Attenuates Depression-Related Symptoms in Mice with Moderate Traumatic Brain Injury. Cells 2023, 12, 1040

Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza et autres

In the original publication [...].

Nrf2/ NOX2 Pathway Dysregulation and Oxidative Stress Biomarkers in Gaucher Disease–Associated Parkinsonism: Insights Into a Potential Therapeutic Target

Alessio Ardizzone, Marika Lanza, Anna Paola Capra, Giovanna Casili et autres

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder, yet its underlying genetic and molecular mechanisms remain incompletely understood. Variants in the GBA gene, encoding the lysosomal enzyme glucocerebrosidase, are not only responsible for Gaucher disease (GD) but also represent a …

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RETRACTED: Scuderi et al. Efficacy of a Product Containing Xyloglucan and Pea Protein on Intestinal Barrier Function in a Partial Restraint Stress Animal Model. Int. J. Mol. Sci. 2022, 23, 2269

Sarah Adriana Scuderi, Giovanna Casili, Marika Lanza, Alessio Ardizzone et autres

The journal retracts the article titled "Efficacy of a Product Containing Xyloglucan and Pea Protein on Intestinal Barrier Function in a Partial Restraint Stress Animal Model" [...].

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Aberrant Cell Cycle Gene Expression in a Transgenic Mouse Model of Alzheimer’s Disease

Marika Lanza, Michele Scuruchi, Alessandra Saitta, Rossella Basilotta et autres

Alzheimer’s disease (AD) is increasingly recognized as a disorder that extends beyond amyloid-β (Aβ) and tau pathology. To this end, growing evidence suggests that aberrant neuronal cell cycle re-entry (CCR) may contribute to neurodegeneration. To investigate this mechanism, we profiled the expression …

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Aesculus hippocastanum Extract Exerts Neuroprotective Effects in an MPP + ‐Induced Parkinson's Disease Model via PPARγ Activation

Sarah Adriana Scuderi, Alessio Ardizzone, Giovanna Casili, Deborah Mannino et autres

ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the loss of dopaminergic neurons in the substantia nigra. In this study, we investigated the neuroprotective and anti‐inflammatory potential of Aesculus hippocastanum (horse chestnut extract, HCE) in an in vitro model …

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Pharmacological Inhibition of EZH2 by GSK ‐343 Attenuates Neuroinflammation in a Mouse Model of Spinal Cord Injury

Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici et autres

Spinal cord injury (SCI) is a devastating condition with limited therapeutic options and a strong neuroinflammatory component that exacerbates tissue damage and impairs functional recovery. Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and core component of the Polycomb Repressive Complex …

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Tempol Ameliorates Psoriatic Skin Inflammation: Evidence of TLR4/NF‐κB/Nrf2 Axis Modulation

Sarah Adriana Scuderi, Marika Lanza, Anna Paola Capra, Antonio Catalfamo et autres

Psoriasis is a chronic inflammatory skin disorder characterized by keratinocyte hyperproliferation, immune dysregulation, oxidative stress, and impaired epidermal barrier function. In the present study, we investigated the protective effects of Tempol, a membrane-permeable nitroxide with antioxidant and anti-inflammatory properties, using several psoriasiform …

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Author response for "Pharmacological inhibition of EZH2 by GSK-343 attenuates neuroinflammation in a mouse model of spinal cord injury"

Yinhui Kang, Deborah Mannino, Valentina Bova, Alberto Repici et autres

P18.21.A MODULATION OF THE L-CYSTEINE/H₂S/L-SERINE/S1P AXIS IN GLIOBLASTOMA: IMPLICATIONS OF HYDROGEN SULFIDE IN TUMOR PROGRESSION

Giovanna Casili, Michele Correale, Rossella Basilotta, Maria Caffo et autres

Abstract BACKGROUND Sphingosine-1-phosphate (S1P) is a key signaling molecule involved in the progression of several cancers, including glioblastoma multiforme (GBM), the most aggressive primary brain tumor. Recent findings suggest that S1P originates from L-serine, a product of the transsulfuration pathway during the …

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PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD

Marika Lanza, Rossella Basilotta, Antonella Caccamo, Giovanna Casili et autres

Alzheimer's disease (AD) is a neurodegenerative disorder that significantly impacts the lives of patients and their families. The pathological features of AD include the accumulation of amyloid-β (Aβ) and Tau, which disrupt neuronal function and communication, ultimately leading to neuronal loss and …

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