Two Unrelated Families With Noncoding Duplications Upstream of MSX2 Refine the Critical Regulatory Region Likely Involved in Cranial Bone Development and a Cleidocranial Dysplasia‐Like Phenotype
Mamiko Yamada, Mark Cleghorn, Prabhakara Krishnamurthy, Tegan French et autres
Cleidocranial dysplasia (CCD) is a genetic disorder characterized by delayed cranial suture closure, hypoplastic clavicles, and dental anomalies, with varying severity. Most cases are linked to RUNX2 variants; however, rare CCD‐like phenotypes can arise from other genetic alterations, including variants in MSX2 …
jp, au (code pays fourni par la source)
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Human Mutation