Increasing Cancer Stemness Drives Prostate Cancer Progression, Plasticity, Therapy Resistance and Poor Patient Survival
Xiaozhuo Liu, Anmbreen Jamroze, Eduardo Cortes, Yibing Ji et autres
Abstract Background Cancer progression is often accompanied by dedifferentiation and acquisition of stem cell-like properties (stemness). In prostate cancer (PCa), lineage plasticity and therapy resistance remain major clinical challenges, yet a unified quantitative transcriptomic framework connecting stemness, androgen receptor (AR) signaling, castration …
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bioRxiv (Cold Spring Harbor Laboratory)