AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins
Bianca Broske, Benjamin A. McEnroe, Sophie C. Binder, Tim Kempchen et autres
Experimental validation and functional optimization remain bottlenecks in AI-based protein design. We present a scalable workflow for developing AI-designed minibinders against cancer-associated surface proteins. Screening thousands of designs using mammalian cell-surface display identifies several high-affinity PD-L1 minibinders but far fewer for CD276 …
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Nature Communications