Live brain biopsy during CSF shunt surgery for precision diagnostics and multi-omic research
Heikki E. M. Lukkarinen, Antti J. Luikku, Antonios Dougalis, Anssi Pelkonen et autres
Abstract Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibrillary tau …
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Alzheimer s Research & Therapy