Impaired nitrogenous waste clearance promotes hepatocellular carcinoma
Xinlu Han, Jianliang Shen, Junrong Yan, Rahul Tacke et autres
In mammals, hepatic urea cycle enzymes (UCEs) convert ammonia, the toxic nitrogenous waste, into urea for excretion. In hepatocellular carcinoma (HCC), UCE expression is often heterogeneously repressed, but its role in tumorigenesis is unclear. We show that, as in patients, UCE expression …
us, cn (code pays fourni par la source)
5 citations
Science Advances