Accès ouvert
2026
article
OpenAlex
Natalie Mackow, Wanying Shao, Lizhao Ge, Lauren Komarow et autres
BACKGROUND: Ceftriaxone-resistant Escherichia coli infections are increasingly common, partially because of the emergence of E. coli sequence type 131 (ST131), including its subclade C2/H30Rx, which produce extended-spectrum β-lactamases. METHODS: A prospective cohort including 14 US sites, which enrolled monomicrobial ceftriaxone-resistant and susceptible …
us
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Accès ouvert
2026
article
OpenAlex
Steven Marshall, Daniel D Rhoads, Liang Chen, Federico Perez et autres
We characterized the molecular determinants of meropenem-vaborbactam (MV) non-susceptibility among non-metallo-β-lactamase-producing KPC-Klebsiella pneumoniae (KPC-KP). Whole-genome sequencing was performed to identify mutations associated with MV non-susceptibility. Isolates with elevated MV MICs were found to have mutations encoding truncated or altered OmpK36 porins and …
us
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Accès ouvert
2026
article
OpenAlex
Elaine J. Kim, Madison Ponder, Luther A. Bartelt, Anne Friedland et autres
Abstract Background Desirability of Outcome Ranking (DOOR) analysis provides a global assessment of patient outcomes by accounting for both benefits and harms in a single outcome measure. Currently, there is no standardized DOOR framework for patients on outpatient parenteral antimicrobial therapy (OPAT). …
us
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Accès ouvert
2026
article
OpenAlex
Madison Stellfox, Lauren Komarow, Robin Patel, David van Duin et autres
Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAb) is a multi-drug resistant, opportunistic pathogen. Colistin is one of a few remaining treatment options, but resistance exists globally. Methods Between 2017 and 2019, 551 CRAb isolates were collected through the international Study Network of Acinetobacter …
us
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Accès ouvert
2026
article
OpenAlex
Heather Henderson, Billy J Williams, Kevin Alby, David van Duin
Abstract Background Antimicrobial resistance is a global health emergency that disproportionately affects vulnerable populations. We evaluated whether the prevalence of multidrug resistance (MDR) in Enterobacterales clinical isolates varied according to neighborhood deprivation level among patients of a health system in North Carolina.TableMultidrug …
us
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Accès ouvert
2026
article
OpenAlex
Yuya Kawamoto, K. Uemura, Yasufumi Matsumara, Ryota Hase et autres
Abstract Background Carbapenem-resistant Gram-negative bacilli (CR-GNB) infections are associated with high mortality and increased healthcare costs. While certain resistant pathogens, such as extended-spectrum β-lactamase-producing organisms, are increasingly identified in the community, reports of community-associated CR-GNB infections remain limited, particularly in high-income countries …
jp, us
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Accès ouvert
2026
article
OpenAlex
Angelique E Boutzoukas, Jiahe Tian, Lauren Komarow, Lizhao Ge et autres
Abstract Background Risk factors for mortality among patients with carbapenem-resistant (CR) Gram-negative infections have been extensively studied, however children and younger adults with CR Gram-negative infections are underrepresented in these studies.Table 1.Demographics for included patients aged 2-30 years with carbapenem-resistant isolates (N=434)Figure …
us, cn, sa, au
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Accès ouvert
2026
article
OpenAlex
Angelique E Boutzoukas, Wanying Shao, Jianping Jiang, Souha S Kanj et autres
Abstract Background Treatment options for Carbapenem-resistant (CR) Gram-negative infections due to metallo-beta-lactamase (MBL) enzymes are limited. The clinical impact of MBLs vs. other mechanisms of carbapenem resistance in Enterobacterales and non-fermenting bacteria remains unclear.Table 1.Demographics, isolate characteristics, and outcomes of patients with …
us, lb, cn, co, sg, au
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Accès ouvert
2026
article
OpenAlex
Jianping Jiang, Lauren Komarow, YIXUAN LI, Angelique E Boutzoukas et autres
Abstract Background Despite growing reports of virulence gene acquisition in carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, the clinical implications of these infections remain poorly understood. Methods In this study, 246 hospitalized patients with clinical CRKP infections were enrolled from six hospitals across China …
us, cn
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