Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao et autres
Septic cardiomyopathy is a life-threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN-I signaling pathway through a mono-ADP-ribosylation-dependent interaction with TBK1. Here, through comprehensive analysis of the expression profile of the PARP …
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