Accès ouvert
2025
article
OpenAlex
Zhaopei Liu, Kaifeng Jin, Zhen-Bin Xu, Han Zeng et autres
INTRODUCTION: Disitamab Vedotin (DV), a HER-2-targeting antibody-drug conjugate, has exhibited substantial clinical advantages in individuals with metastatic urothelial carcinoma (mUC). Nonetheless, the extent of therapeutic efficacy in real-world scenarios for mUC patients and the specific patient profiles with the most benefit from …
cn
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Accès ouvert
2025
article
OpenAlex
Kaifeng Jin, Yawei Ding, Jingtong Xu, Zhaopei Liu et autres
Background The E3 ubiquitin ligase murine double minute 2 (MDM2) binds the p53 transcriptional activation domain and acts as a potent inhibitor of TP53 pathway, one of the three most crucial oncogenic pathways in urothelial carcinoma (UC). However, the clinical significance and …
cn
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Accès ouvert
2023
article
OpenAlex
Zhaopei Liu, Kaifeng Jin, Ziyue Xu, Jingtong Xu et autres
Objective KDM6A, a representative tumour suppressor gene with sex bias, is frequently altered in urothelial carcinoma (UC). The specific impacts of KDM6A mutations on gender-based clinical outcomes in UC remain poorly understood. Methods and analysis We enrolled 2438 patients with UC from …
cn
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