Ziyue Xu

Activity-dependent DNA methylation and demethylation: epigenetic regulators of learning and memory

Zhehao Li, Ziyue Xu, Xuefeng Li, Haobin Ren et autres

Learning and memory are fundamental cognitive processes that rely on activity-dependent epigenetic mechanisms to shape synaptic and neuronal plasticity. Among these, DNA methylation and demethylation have emerged as pivotal regulators that convert transient neural activity into enduring transcriptional programs. In mammals, DNA …

cn, hk (code pays fourni par la source)

A Forsythiaside A-loaded, oxygen-releasing thermosensitive hydrogel accelerates diabetic wound healing by remodeling the microenvironment

Wenbo Mu, Peng Tuo, Yihan Hu, Liangjie Xie et autres

The healing of diabetic wounds is severely compromised by an adverse microenvironment characterized by persistent hypoxia, infection, and inflammation, necessitating the development of innovative and integrated therapeutic strategies. To address these challenges, we have engineered a multifunctional hydrogel (OTH-FTA) by incorporating an …

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Interfacial pH and O2 evolution during molybdenum degradation for understanding cytocompatibility

Cheng Wang, Yuxuan Li, Yi Shao, Chao Sun et autres

Direct culturing Human Umbilical Vein Endothelial cells (HUVECs) on Mo reduced viability by ~50% from 24 to 48 h, while an equivalent Mo species maintained >80%, showing cytotoxicity stems from interfacial processes. Local analysis at Mo interface in Hanks’ solution revealed minimal …

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A dual-mechanism injectable hydrogel integrating reactive oxygen species regulationand low-level laser therapy for androgenetic alopecia remediation

Yi-Xiang Wang, Kang Fu, Yue Yu, Ziyue Xu et autres

Androgenetic Alopecia (AGA) is a chronic disease characterized by follicular degenerative changes and the continuous deterioration of the follicular microenvironment. Excessive accumulation of reactive oxygen species (ROS) and insufficient local microcirculation are both critical factors contributing to the onset and progression of …

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Unlocking new crossing field: In situ surface-enhanced Raman spectroscopy analyzing the alternating current catalytic process and phenomenon for molecular degradation

Jingyi Wei, Junxi Huang, Sixian Yu, Ziyue Xu et autres

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Profiling fear-extinction learning induced small ncRNAs landscape and identifying miR-29b-3p as a promising biomarker for PTSD

Jiazhi Jiang, Junhui Liu, Sha Liu, Wenjing Wang et autres

OBJECTIVE: The pivotal role of small non-coding RNAs (ncRNAs) in gene expression highlights their potential as therapeutic targets and biomarkers in neuropsychiatric disorders. However, their transcriptional dynamics during fear extinction (EXT) remain poorly understood, limiting insights into disorders such as post-traumatic stress …

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Early Detection of Polycystic Ovary Syndrome: A Systematic Evaluation of Machine Learning Models Using Clinical Parameters

Ziyue Xu

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Fe/S co-doped biochar catalysts for enhanced peroxymonosulfate activation: Synergistic effects of catalysis and anti-deactivation on antibiotic degradation

Wangbo Wang, Qiyu Shi, Ting Wu, Shuhan Zheng et autres

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PUS7-dependent Ψ reshapes specific synaptic gene exons to facilitate fear extinction memory formation

Yuhan Dong, Zhipeng Gao, Jichun Shi, Ziyue Xu et autres

RNA modifications serve as dynamic regulators of neural plasticity through their ability to fine-tune transcript stability and splicing. Pseudouridine (Ψ), an evolutionarily conserved RNA modification catalyzed by pseudouridine synthases, plays established roles in neurodevelopment, yet its functional significance in activity-dependent behavioral adaptation …

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Band Structure Engineering to Optimize Spin‐Wave Propagation in Weyl ferromagnet Co 2 MnGa 1‐ x Ge x

Jinlong Wang, Yao Zhang, Junfeng Hu, Song He et autres

Abstract Spin waves, the quantized excitations of magnetic order, have been widely explored as low‐power information carriers in conventional metallic systems (e.g., NiFe) and insulating materials like yttrium iron garnet (YIG). Recently, magnetic Weyl semimetals (WSMs) have emerged as a novel platform …

cn, nz, au (code pays fourni par la source)

A novel small cysteine‐rich protein, PbEL04 , identified from Plasmodiophora brassicae, associates with AtSAMS2 to regulate Arabidopsis clubroot resistance

Xuefei Jiang, Peiyao Li, Xinmeng Li, Xinrui Xu et autres

SUMMARY Plasmodiophora brassicae is a devastating intracellular pathogen that causes clubroot disease in Brassicaceae plants, leading to significant economic losses in agriculture. Enhancing plant resistance against P. brassicae has become a crucial global challenge. In this study, we report a new secreted …

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TERT promoter mutations or protein overexpression define an aggressive subset with favourable immunotherapeutic response in advanced urothelial carcinoma

Kaifeng Jin, Jingtong Xu, Lingkai Zhang, Zhaopei Liu et autres

Objective Telomerase reverse transcriptase (TERT) gene promoter mutation (TPM) is a key non-coding somatic alteration in urothelial carcinoma (UC) that plays a critical role in telomerase activation. Despite its importance, the prognostic value of TPM has shown mixed results in previous studies. …

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