Identification of a NUAK1/2 Inhibitor as a Macrophage-Polarizing Compound by a Machine Learning-Based Phenotypic Cell Painting Screen
Johanna B. Brüggenthies-Brunner, Jakob Dittmer, Julia Sauer, Sarah Groetzner et autres
Disease-associated macrophage states contribute to the pathogenesis of numerous inflammatory disorders. While small molecule-mediated macrophage repolarization represents a promising strategy to restore homeostasis, current approaches often rely on predefined molecular markers and may therefore overlook previously unrecognized modulators of macrophage plasticity. To …
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International Journal of Molecular Sciences