DEVELOPMENT OF A HUMAN IMMUNE SYSTEM EXPERIMENTAL MODEL TO INVESTIGATE IMMUNE CELLS ACTIVATION AND TARGETING FOR CVD
Arianna Moretti, Sara Greco, Annalisa Moregola, Silvia Della Bella et autres
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Atherosclerosis
Arianna Moretti
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3Publications signalées
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Immune Cell Function and InteractionT-cell and B-cell ImmunologyImmune Response and InflammationAdipokines, Inflammation, and Metabolic Diseases3D Printing in Biomedical Research
Les publications récentes
SREBP1c modulates Treg immunobiology through a phospholipid-dependent adenosine pathway
Fabrizia Bonacina, Claudio Procaccini, Marta Iaia, Arianna Moretti et autres
Tregs maintain immune tolerance through mechanisms tightly coupled to cellular metabolism. Whereas glycolysis supports migration of Tregs, lipid metabolism sustains their suppressive phenotype. Here, we identify SREBP1c as a central regulator of Treg immunobiology. Tregs from Srebp1c-deficient mice displayed impaired suppressive function, …
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Journal of Clinical Investigation
Immune-metabolic characterization of a humanized mouse model for translational studies on cardiovascular diseases
Arianna Moretti, Sara Greco, Annalisa Moregola, Christoph J. Binder et autres
Background: Atherosclerosis represents one of the main cardiovascular risk factors and is driven by high plasma cholesterol levels and an impaired immuno-inflammatory response. Despite effective lipid-lowering therapies, some patients exhibit persistent residual inflammatory risk, highlighting the need for experimental models that enable …
it, at (code pays fourni par la source)
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European Atherosclerosis Journal
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