MetaboXcan: A multiomic framework linking genetically predicted metabolites, gene expression, and complex traits
Festus Nyasimi, Sarah Sumner, Yanyu Liang, Xianyong Yin et autres
Abstract Genetically regulated molecular phenotypes, such as gene expression and metabolites, are widely thought to mediate the effect of disease-relevant genetic loci identified by genome-wide association studies (GWAS); however, molecular mechanisms connecting genetic variation to disease remain poorly understood. While transcriptome-wide association …
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bioRxiv (Cold Spring Harbor Laboratory)