Accès ouvert
2026
article
OpenAlex
Phan Q. Duy, Benjamin C. Reeves, Huanxing Sun, Xueyan Peng et autres
Microglia play essential yet poorly understood roles in brain development, including axon guidance, regulation of neurogenesis, and pruning of neuronal projections. Congenital hydrocephalus (CH), characterized by enlarged cerebrospinal fluid (CSF)-filled ventricles, is a leading cause of pediatric brain surgery, but its molecular …
us, gb
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Accès ouvert
2026
retraction
OpenAlex
Jinwei Zhang, Geng Gao, Gulnaz Begum, Jinhua Wang et autres
Following publication, concerns regarding Figure 3C were brought to the attention of the Editors. Six of the eight western blots presented in Figure 3C appear to be highly similar to an earlier publication of the authors 1 where the experimental treatments described …
us, gb, mx
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Accès ouvert
2026
article
OpenAlex
Rubina, Sehrish Jamal, Manming Xu, Saleh Alyemni et autres
Claudin-14 (CLDN14) is a key component of tight junctions (TJs) critical for maintaining paracellular barrier function. Variants of CLDN14 have been linked to Vein of Galen malformations (VOGMs), a rare cerebrovascular disorder; however, the molecular mechanisms underlying their pathogenicity remain unknown. Here, …
pk, gb, sa, us
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Accès ouvert
2026
article
OpenAlex
Heikki E. M. Lukkarinen, Antti J. Luikku, Antonios Dougalis, Anssi Pelkonen et autres
Abstract Diagnostic testing and neurosurgical management involving CSF shunting in patients with idiopathic normal pressure hydrocephalus (iNPH) offers a unique, ethically sustainable opportunity to study the aging human brain. The common co-occurrence of neurodegenerative pathologies such as amyloid-β plaques and neurofibrillary tau …
us, fi, gb, no
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2026
article
OpenAlex
William Davalan, Neel H. Mehta, Andrew T. Hale, Qiang Li et autres
OBJECTIVE: Chiari malformation type I (CM-I) is traditionally conceptualized as a structural disorder of the posterior cranial fossa characterized by cerebellar tonsillar herniation. However, increasing clinical and experimental evidence suggests that CM-I may be associated with distributed neurocognitive and affective sequelae consistent …
us, ca
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Accès ouvert
2026
preprint
OpenAlex
Asan F. Abdulkareem, Noah H. Elste, Rain Younger, Mackenzi L. Prina et autres
Abstract As neurons grow, they must regulate intrinsic excitability to maintain an appropriate level of spiking based on synaptic inputs. Using gene knockouts, phosphoproteomics, and electrophysiology we show PTEN regulates neuronal growth and intrinsic excitability through separable downstream mechanisms. Pten loss induces …
us
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Accès ouvert
2020
article
OpenAlex
Jinwei Zhang, Mohammad Iqbal H. Bhuiyan, Ting Zhang, Jason K. Karimy et autres
cotransporters (CCC), including NKCC1 and the KCCs, are important determinants of brain ionic homeostasis. SPAK kinase (STK39) is the CCC master regulator, which stimulates NKCC1 ionic influx and inhibits KCC-mediated efflux via phosphorylation at conserved, shared motifs. Upregulation of SPAK-dependent CCC phosphorylation …
cn, gb, us
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