Mechanistic and machine learning models design human gut consortia that robustly inhibit Clostridioides difficile
Hanhyeok Im, Yiyi Liu, Jaron Thompson, Gabriel Ignacio Miranda et autres
ABSTRACT Identifying design principles for robust inhibition of human pathogens is a major goal of microbiome engineering. By building synthetic microbial communities from the bottom-up guided by Bayesian active learning, we investigate the Clostridioides difficile growth landscape across thousands of species-metabolite conditions. …
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bioRxiv (Cold Spring Harbor Laboratory)