Katja von Hoff

ID #967 PNOC031: An International Trial for Embryonal Tumor with Multilayered Rosettes (ETMR)

Derek Hanson, Susan Chi, Katja von Hoff, B Pizer et autres

Abstract Background Embryonal tumor with multilayered rosettes (ETMR) is a rare, highly aggressive central nervous system embryonal tumor primarily affecting infants and young children, with poor outcomes despite intensive multimodality therapy. Retrospective data are limited by heterogeneous regimens and small cohorts, complicating …

us, dk, gb, nl, at, au, ch (code pays fourni par la source)

ID #623 Modelling CNS tumors with BCOR alterations for understanding biology and therapy development

Francesco Bernaudo, Chantal Giebel, Phylicia Stathi, Álvaro Regano et autres

Abstract Central nervous system tumors with BCOR alterations (CNS-BCOR) represent a recently discovered brain tumor type. DNA methylation data and transcriptome analyses revealed two distinct but highly related subtypes, carrying either an internal tandem duplication (ITD) in exon 15 of BCOR (BCOR-ITD) …

nl, de, ca, at, dk (code pays fourni par la source)

ID #650 Learning From Every Rare Case: The Early Impact of an International Pediatric Rare Brain Tumor Board

Hope Lovell, Gilbert Vezina, Cheng–Chia Wu, Kristian Aquilina et autres

Abstract Background Rare pediatric and young adult brain tumors pose major diagnostic and therapeutic challenges due to limited evidence and scattered expertise. The International Rare Brain Tumor Board was established to enable multidisciplinary case review, shared learning, and collaborative decision support. Methods …

us, in, gb, my, dk, at (code pays fourni par la source)

Incomplete tumor resection, central neuroradiological review, and second surgery in pediatric patients with intracranial ependymoma treated in the E-HIT2000 trial

Kara L. Krajewski, Gertrud Kammler, Denise Obrecht-Sturm, Martin Mynarek et autres

OBJECTIVE: The purpose of this study was to review the assessment of residual tumor, analyze surgical factors associated with incomplete resection, determine the risk of neurological sequelae for reoperation, and assess the impact of second surgeries on survival. METHODS: Patients 0-21 years …

de, ch, at, us, dk (code pays fourni par la source)

HEALTH-RELATED QUALITY OF LIFE IN MOLECULAR SUBGROUPS OF MEDULLOBLASTOMA

Veronika Faltermeier, Christian Hagel, K Petrasch, Renate Schmid et autres

PROGNOSTIC RELEVANCE OF EPIGENETIC/BIOLOGICAL SUBGROUPS AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT AGED 4-21 YEARS

Andre Oscar von Bueren, David T. W. Jones, Tobias Goschzik, Rolf-Dieter Kortmann et autres

NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES

Martin Benesch, Martin Mynarek, Klaus Mueller, Monika Warmuth‐Metz et autres

INTENSIFICATION OF INDUCTION CHEMOTHERAPY IMPROVES OUTCOMES IN PATIENTS WITH METASTATIC MEDULLOBLASTOMA BELOW 4 YEARS OF AGE: RESULTS OF A PROSPECTIVE, NON-RANDOMIZED PHASE II CLINICAL TRIAL

Martin Mynarek, Katja von Hoff, Klaus Mueller, Carsten Friedrich et autres

LONG-TERM FOLLOW-UP OF CHILDREN WITH EPENDYMOMA TREATED ACCORDING TO HIT-TRIALS 1987-1998

Martin Mynarek, Rolf-Dieter Kortmann, Peter Kaatsch, Torsten Pietsch et autres

PRIMITIVE NEUROECTODERMAL TUMORS OF THE BRAINSTEM: CLINICAL FINDINGS OF A RARE DISEASE WITH A VERY UNFAVORABLE DIAGNOSIS

Carsten Friedrich, Monika Warmuth‐Metz, Andre Oscar von Bueren, Johannes Nowak et autres

PROGNOSTIC IMPACT OF HISTOPATHOLOGY, WNT ACTIVATION AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT

Stefan Rutkowski, André Von Bueren, Tobias Goschzik, Rolf Kortmann et autres

RISK-ADAPTED TREATMENT FOR NON-METASTATIC EPENDYMOMA: PRELIMINARY RESULTS OF THE NON-RANDOMIZED PROSPECTIVE PHASE II CLINICAL TRIAL HIT2000

Katja von Hoff, Rolf-Dieter Kortmann, Nicolas U. Gerber, Martin Mynarek et autres