IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes
Agatha Ribeiro Kalthof, Nikolas D. Ferreira, Caio Mateus da Silva, Iuri Cordeiro Valadão et autres
Generating mature human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) remains a major obstacle to accurate disease modeling and cardiac repair. As the transcription factor Irx3 is a key determinant of ventricular conduction system fate in mice, we hypothesized that suppressing IRX3 expression …
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PLoS ONE