A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells
Yu Liu, Kejia Zhao, Binbin Hu, Jiufeng Tan et autres
The evolution of drug-tolerant persister (DTP) cells into resistant clones remains a major clinical obstacle to targeted therapies. Transcriptomic profiling across melanoma (A375, SK-MEL-28), non-small cell lung cancer (NSCLC; HCC827, PC-9), and colorectal cancer (CRC; SW480) models revealed a conserved biphasic telomerase …
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