Accès ouvert
2026
preprint
OpenAlex
Grayson Herrgott, Luciano Garofano, Natalia S. Morosini, Bogdan Done et autres
Abstract IDH-mutant gliomas stratified by glioma CpG island methylator phenotype (G-CIMP) into High (GCH) and Low (GCL) exhibit markedly divergent clinical outcomes, yet cellular and regulatory determinants of this distinction remain incompletely defined. Integrating single-nucleus RNA-and ATAC-sequencing across 18 tumor specimens from …
us
(code pays fourni par la source)
2026
article
OpenAlex
Tavarekere N. Nagaraja, Seamus Bartlett, Glauber Cabral, Prabhu C. Acharya et autres
OBJECTIVE: Image-guided laser interstitial thermal therapy (LITT) is a minimally invasive cytoreductive treatment for recurrent gliomas and tumors in eloquent regions. This technique was adapted to develop an image-guided glioblastoma (GBM) ablation model of recurrence. The efficacy of imaging biomarkers for evaluating …
us
(code pays fourni par la source)
2026
article
OpenAlex
Jack P. Rock, Grayson Hergott, Kristyn Quenneville, Simona Cazacu et autres
Introduction: Nonfunctioning pituitary neuroendocrine tumors (NF-PitNETs) are the most common pituitary tumors requiring surgery. Although hormonally silent, they often cause mass effects, recur and may grow aggressively. Current pathology and imaging fail to predict which tumors will progress, and no medical therapies …
us
(code pays fourni par la source)
Accès ouvert
2018
peer-review
OpenAlex
Tiago C. Silva, Antonio Colaprico, Catharina Olsen, Tathiane M. Malta et autres
The GDC (Genomic Data Commons) data portal provides users with data from cancer genomics studies. Recently, we developed the R/Bioconductor TCGAbiolinks package, which allows users to search, download and prepare cancer genomics data for integrative data analysis. The use of this package …
us, br, be, in, it
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Yang Liu, Nilay S. Sethi, Toshinori Hinoue, Barbara Schneider et autres
We analyzed 921 adenocarcinomas of the esophagus, stomach, colon, and rectum to examine shared and distinguishing molecular characteristics of gastrointestinal tract adenocarcinomas (GIACs). Hypermutated tumors were distinct regardless of cancer type and comprised those enriched for insertions/deletions, representing microsatellite instability cases with …
us, ca, be
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Vésteinn Thórsson, Vésteinn Thorsson, David L. Gibbs, Scott Brown et autres
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-characterized by …
us, ca, es, be, qa, br
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Joel Saltz, Rajarsi Gupta, Le Hou, Tahsin Kurç et autres
Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through …
us
(code pays fourni par la source)
Accès ouvert
2017
peer-review
OpenAlex
Tiago C. Silva, Antonio Colaprico, Catharina Olsen, Fulvio D’Angelo et autres
Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA) , The Encyclopedia of DNA Elements (ENCODE) , and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap) . These …
us, br, in, it, qa
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Robert D. Burk, Zigui Chen, Saller Cf, Katherine Tarvin et autres
Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns …
us, br, ca, Nigéria
(code pays fourni par la source)
Accès ouvert
2016
peer-review
OpenAlex
Tiago C. Silva, Antonio Colaprico, Catharina Olsen, Fulvio D’Angelo et autres
Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA) , The Encyclopedia of DNA Elements (ENCODE) , and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap) . These …
br, in, it, qa
(code pays fourni par la source)
Accès ouvert
2016
peer-review
OpenAlex
Tiago C. Silva, Antonio Colaprico, Catharina Olsen, Fulvio D’Angelo et autres
Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA) , The Encyclopedia of DNA Elements (ENCODE) , and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap) . These …
br, in, it, qa
(code pays fourni par la source)