Thomas A. Jepps

Physiological 17β-oestradiol inhibits KV7.4 currents via GPER1-dependent PLC/PKC signalling

Elif Karabatak, Skye Lau, Samantha C. Salvage, Thomas A. Jepps et autres

KV7.4 channels are important regulators of membrane potential and excitability in multiple tissues and are emerging as key effectors of steroid hormone signaling. Here, 17β-estradiol (E2) was examined as a modulator of recombinant KV7.4 channels expressed in HEK293 cells. Whole-cell patch-clamp recordings …

Physiological 17β-oestradiol inhibits KV7.4 currents via GPER1-dependent PLC/PKC signalling

Elif Karabatak, Skye Lau, Samantha C. Salvage, Thomas A. Jepps et autres

KV7.4 channels are important regulators of membrane potential and excitability in multiple tissues and are emerging as key effectors of steroid hormone signaling. Here, 17β-estradiol (E2) was examined as a modulator of recombinant KV7.4 channels expressed in HEK293 cells. Whole-cell patch-clamp recordings …

A Randomized Trial to Investigate the Effects of Low‐Dose Colchicine in Patients with Hypertension: Rationale and Design of the COlchicine and HypERtENsion Trial (COHERENT)

Adam Femerling Langhoff, Niklas Dyrby Johansen, Marie Frimodt‐Møller, Ahmad Sajadieh et autres

Hypertension is a prevalent and significant risk factor for cardiovascular disease (CVD). The immune system and inflammatory response are involved in the pathophysiology of hypertension. We hypothesize that treating hypertension with colchicine on top of standard therapy, will decrease pulse wave velocity …

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