Peak width of skeletonized mean diffusivity reveals early and multifactorial white matter injury across sporadic and Down syndrome–associated Alzheimer's disease
Alejandra O. Morcillo‐Nieto, María Franquesa‐Mullerat, Sara E. Zsadanyi, José Enrique Arriola‐Infante et autres
INTRODUCTION: This study investigates the evolution with disease progression and pathological correlates of peak width of skeletonized mean diffusivity (PSMD), a sensitive diffusion magnetic resonance imaging (MRI) marker of microvascular white matter (WM) injury, in sporadic Alzheimer's disease (sAD) and Down syndrome …
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Alzheimer s & Dementia