A complement atlas of head and neck squamous cell carcinomas to reveal intratumoral complement control and identify factor H as a therapeutic target in oral cavity and HPV-negative oropharyngeal tumors.
Joey Martin, Constance Lamy, Houcine Hamidi, Nicolas Merle et autres
e18049 Background: Oral Cavity Squamous Cell Carcinoma (OCSCC) and HPV-negative oropharyngeal SCC (HPV-negative OPSCC) together account for nearly 40% of Head and Neck SCC (HNSCC) and remain an unmet clinical need, with poor prognosis and limited benefit from multimodal therapies, including immune …
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Journal of Clinical Oncology