Niels Kloosterhuis

SMLR1: A NOVEL REGULATOR IN BOTH VLDL AND CHYLOMICRON METABOLISM

Ankia Visser, Floris Feiner, Marieke Smit, Niels Kloosterhuis et autres

Hepatocyte-specific Cas9-mediated editing of G6pc and Slc37a4 elicits comparable biochemical and regulatory responses between glycogen storage disease (GSD) type Ia and Ib mice

Kishore Alagere Krishnamurthy, Ruiqi Xiao, Martijn G. S. Rutten, Trijnie Bos et autres

BACKGROUND/OBJECTIVE: Glycogen storage disease type I (GSD I) is an autosomal recessive inborn error of carbohydrate metabolism. Patients with GSD type Ia and Ib exhibit overlapping and distinct symptoms and complications. Notably, GSD Ia patients show more severe hypertriglyceridemia and higher risk …

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SAT-221-YI Liver-specific deletion of Gpr146 and Angptl3 reduces plasma lipids and prevents development of diet-induced hepatic steatosis in mice

Umesh Tharehalli, Boyan Zhang, Antoine Rimbert, Nicolette Huijkman et autres

SAT-090 Liver-specific somatic beta-klotho knockout dysregulates hepatic lipid metabolism and increases bile acid synthesis

Alexandra Aaldijk, Cristy Verzijl, Milaine Hovingh, Nicolette Huijkman et autres